Detailed description page of Hmrbase2

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10309 details
Primary information
ID10309
Uniprot IDQ04617
DescriptionCorticotropin-lipotropin A precursor (Pro-opiomelanocortin A) (POMC A)[Cleaved into- - NPP 1; Corticotropin (Adrenocorticotropic hormone) (ACTH);Melanotropin alpha 1 (Alpha-MSH 1); Corticotropin-like intermediarypeptide 1 (CLIP-1); Lipotropin beta (Beta-LPH); Lipotropin gamma(Gamma-LPH); Melanotropi
OrganismOncorhynchus mykiss
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei;Protacanthopterygii; Salmoniformes; Salmonidae; Oncorhynchus.
Subcellular LocationSecreted
Developmental StageExpressed in sexually active or inactive fish.
SimilarityBelongs to the POMC family.
Tissue SpecificityPituitary and hypothalamus of adult diploid animals; and hypothalamus of triploid and ovulated female trout
Post Translational ModificationSpecific enzymatic cleavages at paired basic residues yield the different active peptides. Acetylation of beta-endorphin occurs in a tissue-specific manner.
FunctionNA
Length253
Molecular Weight28559
NameCorticotropin
SequenceSYSMEHFRWGKPVGRKRRPVKVYTNGVEEESSEAFPSEM
Sequence map39 (104-142)
PDB IDNA
DrugpediaNA
ReceptorQ6QLQ0;Q6QLQ1
DomainNA
Pharmaceutical UseNA