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10108 details
Primary information
ID10108
Uniprot IDQ9BEF8
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Cleaved into- - Ghrelin; Obestatin].
OrganismCanis familiaris
TxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis.
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the motilin family.
Tissue SpecificityNA
Post Translational ModificationO-n-octanoylation is essential for ghrelin activity. Amidation of Leu-98 is essential for obestatin activity.
FunctionGhrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect; induces adiposity and stimulates gastric acid secretion. Involved in growth regulation
Length117
Molecular Weight13007
NameGhrelin
SequenceGSSFLSPEHQKLQQRKESKKPPAKLQPR
Sequence map28 (24-51)
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA