| Primary information |
|---|
| ID | 10083 |
| Uniprot ID | Q9VD83 |
| Description | Bursicon precursor (Bursicon subunit alpha) (Cuticle-tanning hormone). |
| Organism | Drosophila melanogaster |
| Txonomy | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila. |
| Subcellular Location | Secreted |
| Developmental Stage | Expression is low in larval stages and increases before ecdysis; consistent with role in postecdysial cuticle changes. |
| Similarity | Cleaved into- 1 CTCK (C-terminal cystine knot-like) domain. |
| Tissue Specificity | Expressed in one to two pairs of neurons in each of the thoracic and abdominal neuromeres of the larval CNS. Coexpressed with CCAP in most CCAP-specific neurons. Coexpressed with pburs in four bilater |
| Post Translational Modification | NA |
| Function | Final heterodimeric neurohormone released at the end of the molting cycle; involved in the sclerotization (tanning) of the insect cuticle; melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk |
| Length | 173 |
| Molecular Weight | 19223 |
| Name | Bursicon |
| Sequence | QPDSSVAATDNDITHLGDDCQVTPVIHVLQYPGCVPKPIPSFACVGRCASYIQVSGSKIWQMERSCMCCQESGEREAAVSLFCPKVKPGERKFKKVLTKAPLECMCRPCTSIEESGIIPQEIAGYSDEGPLNNHFRRIALQ |
| Sequence map | 141 (33-173) |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|