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20033 details
Primary information
ID20033
Pubchem ID222786
NameCortisone
DescriptionA naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale; The Extra Pharmacopoeia; 30th ed; p726)
SynonymAdrenalex Cortisate Cortistal Cortivite Andreson Cortisal Cortogen Cortone Adreson Cortisone
Molecular Weight360.44
FormulaC21H28O5
IUPAC(8S;9S;10R;13S;14S;17R)-17-hydroxy-17-(2-hydroxyacetyl)-10;13-dimethyl-1;2;6;7;8;9;12;14;15;16-decahydrocyclopenta[a]phenanthrene-3;11-dione
SMILECC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
PDB ID3EB3
KEGGC00762; D07749
HMDB IDHMDB0002802
Melting Point (Degree C)222
Water Solubility280mg/ml at 25C
Drugbank IDNA
ReceptorP79686; Q6XLJ0; P49115; P04150; P06537; P49843; O73673; Q9N1U3; Q5R9P5; P59667; P06536; P79269; O13186; O46567; P35547; Q95267; P49844; Q3MSN1; Q3MSN4
ReferencePubchem; HMDB