A database of hormones and their receptors
Non-peptide Hormone

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HMRbase accession number1108
PubChem ID5994
Hormone nameProgestrone
DescriptionThe major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
SynonymsProgesterone Crinone Luteohormone Progesteronum Syngesterone Prometrium Utrogestan Cyclogest Progestin Agolutin
Molecular weight314.46
Molecular formulaC21H30O2
IUPAC Name(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Canonical smilesCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Isomeric smilesCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C
Structure
   
PDB file
SDF file
MOL file
PDB ID1W0F  1YA3  2AA5  2AA6  2ABA  2HZQ  2O5Y  1DBB  1A28  
KEGG IDC00410  D00066  
HMDB IDHMDB01830
Melting Point121(EXP)
Log P3.87(EXP)
Water Solubility8.81(EXP) at 25C
DrugBank IDDB00396
Drugpediawiki
ReceptorP03372   Detail in HMRbase   
P06401   Detail in HMRbase   
Comments
ReferencesPubchem,HMDB