A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11539 |
| Swiss-prot Accession number | P50596 (Sequence in FASTA format) |
| Description | Leptin;Alternative Name: Obesity factor; Precursor |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the leptin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of Lep may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
| Protein Length | 167 Amino acids |
| Molecular weight | 18866 |
| References | 1 PubMed abstract 7657834 2 PubMed abstract 7794258 3 PubMed abstract 7733988 |
| Domain Name | Leptin |
| Hormone Name | Leptin |
| Mature Hormone Sequence | |
| Position of mature hormone in Pre-Hormone protein | |
| Receptor | Q62959 Detail in HMRbase Q9JLS8 Detail in HMRbase Q6PDU4 Detail in HMRbase |
| Gene ID | 25608 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |