A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11522
Swiss-prot Accession numberP50595 (Sequence in FASTA format)
DescriptionLeptin;Alternative Name: Obesity factor; Precursor
Source organismBos taurus (Bovine)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos.
Subcellular locationSecreted (Probable)
Developmental StageN/A
Similarity Belongs to the leptin family.
Tissue SpecificityN/A
Post translational modification N/A
Function May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Protein Length167 Amino acids
Molecular weight18716
References1  PubMed abstract 10594237
2  PubMed abstract 14629116
3  PubMed abstract 16305752
4  PubMed abstract 8661738
Domain NameLeptin  
Hormone NameLeptin
Mature Hormone Sequence
Position of mature hormone in Pre-Hormone protein
ReceptorQ32PD8   Detail in HMRbase   
Q3SYT0   Detail in HMRbase   
Q59HQ0   Detail in HMRbase   
Q5KQU4   Detail in HMRbase   
Q5KQU5    Detail in HMRbase   
Gene ID280836      
PDB ID2A16      
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