A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11482
Swiss-prot Accession numberP56942 (Sequence in FASTA format)
DescriptionPro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)].
Source organismMus musculus (Mouse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular locationSecreted protein (By similarity)
Developmental StageExpression is enhanced between postnatal days 10 and 15.
Similarity Belongs to the MCH family.
Tissue SpecificityPredominantly expressed in hypothalamus. Also found in heart, intestine, spleen and testis (spermatogonia, early spermatocytes and Sertoli cells). In brain only mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly
Post translational modification Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide.
FunctionN/A
Protein Length166 Amino acids
Molecular weight18645
References1   Breton C., Presse F., Hervieu G., Nahon J.-L.; "Structure and regulation of the mouse melanin-concentrating hormonemRNA and gene."; Mol. Cell. Neurosci. 4:271-284(1993).
2  PubMed abstract 10037747
3  PubMed abstract 8724342
Domain NamePro-MCH  
Hormone NameNeuropeptide-glutamic acid-isoleucine
Mature Hormone SequenceEIGDEENSAKFPI
Position of mature hormone in Pre-Hormone protein13 Residues from position (132-144)
ReceptorQ8K3M8   Detail in HMRbase   
Q3UY93    Detail in HMRbase   
Gene IDN/A
PDB IDN/A
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