A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number11359
Swiss-prot Accession numberP01355 (Sequence in FASTA format)
DescriptionCholecystokinins precursor (CCK) [Contains: Cholecystokinin 39(CCK39); Cholecystokinin 33 (CCK33); Cholecystokinin 22 (CCK22);Cholecystokinin 12 (CCK12); Cholecystokinin 8 (CCK8)].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityThe shortest form (CCK8) is predominantly found in the brain, whereas the larger ones are found in the intestine
Post translational modification Cholecystokinin, also known as CCK58, is proteolytically cleaved to produce a number of active cholecystokinins. Sulfation of Tyr-97 is essential for receptor activation.
FunctionThis peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion
Protein Length115 Amino acids
Molecular weight12841
References1  PubMed abstract 2981840
2  PubMed abstract 6199787
3  PubMed abstract 3861130
4  PubMed abstract 6209267
5  PubMed abstract 12479974
6   Varro A., Young J., Gregory H., Csech J., Dockray G.J.; "Isolation, structure and properties of the C-terminal fragment of therat cholecystokinin precursor."; Regul. Pept. 15:195-195(1986).
7  PubMed abstract 8208365
Domain NameGastrin  
Hormone NameCholecystokinin-8
Mature Hormone SequenceDYMGWMDF
Position of mature hormone in Pre-Hormone protein8 Residues from position (96-103)
ReceptorP30553   Detail in HMRbase   
P30551    Detail in HMRbase   
Gene ID25298      
PDB IDN/A
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