A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10339
Swiss-prot Accession numberQ8WXF3 (Sequence in FASTA format)
DescriptionRelaxin-3 precursor (Prorelaxin H3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the insulin family.
Tissue SpecificityN/A
Post translational modification N/A
FunctionMay play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).
Protein Length142 Amino acids
Molecular weight15451
References1   Holloway J.L., Lok S., Jaspers S.R.; "Homo sapiens insulin homolog polypeptide."; Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
2  PubMed abstract 12686464
3  PubMed abstract 12975309
4  PubMed abstract 12506116
5  PubMed abstract 14522968
6  PubMed abstract 14522967
Domain NameN/A
Hormone NameRelaxin-3 A chain
Mature Hormone SequenceDVLAGLSSSCCKWGCSKSEISSLC
Position of mature hormone in Pre-Hormone protein24 Residues from position (119-142)
ReceptorQ9NSD7   Detail in HMRbase   
Q8TDU9   Detail in HMRbase   
Q9HBX9   Detail in HMRbase   
Q8WXD0    Detail in HMRbase   
Gene ID117579      
PDB ID2FHW      
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