A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10326
Swiss-prot Accession numberQ5XXR2 (Sequence in FASTA format)
DescriptionPro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)].
Source organismCanis familiaris (Dog)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis.
Subcellular locationSecreted protein (By similarity)
Developmental StageN/A
Similarity Belongs to the melanin-concentrating hormone family.
Tissue SpecificityN/A
Post translational modification Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6 (By similarity). MCH is a cyclic peptide (By similarity).
FunctionMCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal
Protein Length165 Amino acids
Molecular weight18644
References1   Steflik J., Waters S.M.; "Canine pro-melanin-concentrating hormone."; Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
Domain NamePro-MCH  
Hormone NameMelanin-concentrating hormone
Mature Hormone SequenceDFDMLRCMLGRVYRPCWQV
Position of mature hormone in Pre-Hormone protein19 Residues from position (147-165)
ReceptorQ8MIP5   Detail in HMRbase   
Q8MIP6    Detail in HMRbase   
Gene ID449022      
PDB IDN/A
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