A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10311
Swiss-prot Accession numberQ04617 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin A precursor (Pro-opiomelanocortin A) (POMC A)[Contains: NPP 1; Corticotropin (Adrenocorticotropic hormone) (ACTH);Melanotropin alpha 1 (Alpha-MSH 1); Corticotropin-like intermediarypeptide 1 (CLIP-1); Lipotropin beta (Beta-LPH); Lipotropin gamma(Gamma-LPH); Melanotropin beta 1 (Beta-MSH 1); Beta-endorphin 1; Met-enkephalin].
Source organismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei;Protacanthopterygii; Salmoniformes; Salmonidae; Oncorhynchus.
Subcellular locationSecreted
Developmental StageExpressed in sexually active or inactive fish.
Similarity Belongs to the POMC family.
Tissue SpecificityPituitary and hypothalamus of adult diploid animals, and hypothalamus of triploid and ovulated female trout
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides. Acetylation of beta-endorphin occurs in a tissue-specific manner.
FunctionN/A
Protein Length253 Amino acids
Molecular weight28559
References1  PubMed abstract 1448114
2  PubMed abstract 1448114
Domain NameNPP  ACTH_domain  Op_neuropeptide  
Hormone NameLipotropin beta (Beta-LPH)
Mature Hormone SequenceELGTDDAVYPSLEAGTAEGGEAEGMEGVFSLQEKKDGSYKMNHFRWSGPPASKRYGGFMKSWDERSQKPLLTLFKNVIIKDGQQ
Position of mature hormone in Pre-Hormone protein84 Residues from position (145-228)
ReceptorQ6QLQ0   Detail in HMRbase   
Q6QLQ1    Detail in HMRbase   
Gene ID100136771      
PDB IDN/A
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