A database of hormones and their receptors| A database of hormones and their receptors |
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| Pfam Domain(s) Search Results (E-value <= 1e-3) |
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| Search Parameters | |
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| Keyword | Furin-like |
| Database | Receptor |
| No of entries found | 4 |
| Receptor database Search result 1 | |
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| HMRbase accession number | 20979 |
| Swiss-prot accession number | P06213 |
| Domains | Pkinase_Tyr Recep_L_domain Furin-like Pkinase |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. |
| Receptor database Search result 2 | |
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| HMRbase accession number | 20983 |
| Swiss-prot accession number | P15127 |
| Domains | Pkinase_Tyr Recep_L_domain Furin-like Pkinase |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. |
| Receptor database Search result 3 | |
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| HMRbase accession number | 20984 |
| Swiss-prot accession number | P15208 |
| Domains | Pkinase_Tyr Recep_L_domain Furin-like Pkinase |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. |
| Receptor database Search result 4 | |
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| HMRbase accession number | 21196 |
| Swiss-prot accession number | Q9PVZ4 |
| Domains | Pkinase_Tyr Recep_L_domain Furin-like Pkinase |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. May be required for forelimb regeneration. |