GlycoPP: A web server for predicting glycosylation
sites in prokaryotic proteins

 

About Prokaryotics Glycoproteins

The attachement of carbohydrate to the protein by cotranslational or posttranslational modification is known as glycosylation. Earliar it is believed that glycosylation is only occur in eucaryotics, but later it is discoverd in bacteria also. In bacteria most glycoproteins are associated with virulence factors of medically significant pathogens.So the bacterial glycosylation will become new targets for therapeutic purposes.

Figures: Prokaryotics Glycosylation (figure first, is showing the attachment of glycan at asparagine amino acid in protein, figure first is taken from, "Molecular Biology of the Cell, 4th edition")(Second figure shows the structure of glycoprotein with glycan, PDB: 1HMW)

About Server

GlycoPP: : is a webserver for predicting glycosylation sites of proteins. This webserver takes protein sequences in FASTA format as input and it predict potential N and O glycosylation. The output of predicted results given in tabular format where potential glycosylated residues are shown in Red color.