Epidermal Growth Factor Receptor Inhibitor Database



  1. Distribution of Compounds in differnt inhibitory values
  2. Distribution of Compounds according to number of H-bond Acceeptor
  3. Distribution of Compounds according to number of H-bond Donor
  4. Distribution of Compounds according to the Molecular Mass
  5. Distribution of Compounds according to pI
  6. Distribution of Compounds according to LogP
  7. Distribution of Compounds according to No. of Chiral center
  8. Distribution of Compounds according to Polar Surface Area (PSA)
  9. Distribution of Compounds in IC50 range for EGFR
  10. Distribution of Compounds in IC50 range for ErbB2
  11. Distribution of Compounds in IC50 range for ErbB4
  12. Distribution of Dual inhibitors (EGFR/ErbB2)
  13. Distribution of Covalant inhibitors (EGFR, ErbB2)
  14. Year wise reference distribution
  15. Reference Consulted
  16. Cell Line wise distribution of compounds
  17. Distribution of Compounds in different cell lines


Distribution of compounds
Enzymatic Inhibition Values
IC50 EGFR (3697*) ErbB2 (1170) ErbB4 (55)
L858R (124) T790M (35) L858/T790M (185)
% inhibition EGFR (322) ErbB2 (48)
Ki EGFR (46) ErbB2 (3) ErbB4 (4)
Kd EGFR (13) L868R (13) T790M (4)
L858R/T790M (5) Others (14)
Cellular Inhibition Values of EGFR
Cell IC50 (2057) IC80 (7) GI50 (103)
EC50 (62) GI90 (1) ED50 (2)
% Inhibition (111)
Inhibition Values against other targets
Other protein targets IC50 (1437) Cell line (154) Ki (38)
% inhibition (132)
Dual Inhibitors
IC50 EGFR (636) ErbB2 (618) ErbB4 (18)
Cell line (388)
% inhibition EGFR (52) ErbB2 (41) Cell line (11)
Irreversible inhibitors
IC50 EGFR (406) ErbB2 (186) ErbB4 (15)
Cell line (344)
% inhibition EGFR (4) Cell line (32)

*Digits in bracket represents the number of compounds.

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Graphical Representation of Data
H-bond Acceptor Distribution H-bond Donor Distribution
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Molecular Mass Distribution pI Distribution
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LogP Distribution Chiral Center Distribution
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Polar Surface Area Distribution of Compounds in IC50 range for EGFR
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Distribution of Compounds in IC50 range for ErbB2 Distribution of Compounds in IC50 range for ErbB4
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Distribution of Dual inhibitors in IC50 range Distribution of Covalant inhibitors in IC50 range
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Year wise reference distribution Reference Consulted
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Compound Distribution per Cell line
*A431;1043 (cell line; Number of compounds)
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Distribution of Compounds in differnt Cell lines
S.No.Cell LineNo. of CompoundsS.No.Cell LineNo. of CompoundsS.No.Cell LineNo. of CompoundsS.No.Cell LineNo. of Compounds
1 A431 1043 46 Fak 17 91 SNU1 4 136 Hth104 1
2 SKBR3 331 47 PC3 17 92 SNU16 4 137 Hth7 1
3 BT474 282 48 Sal2 17 93 SNU216 4 138 Hth74 1
4 MCF-7 284 49 SKOV3 17 94 SNU484 4 139 Hth83 1
5 NIH3T3 230 50 Molt-4 16 95 SNU5 4 140 IGROV1 1
6 SW620 219 51 ADPKD 15 96 SNU601 4 141 MDA-MB-157 1
7 A549 191 52 HaCaT 15 97 SNU620 4 142 MDA-MB-436 1
8 N87 164 53 Cal27 13 98 SNU668 4 143 ME18O 1
9 HN5 121 54 CaLu3 14 99 SNU719 4 144 MRC5 1
10 HepG2 120 55 HB4a 13 100 ZR75-1 4 145 NCI-H322M 1
11 KB 96 56 WiDr 13 101 BxPc3 3 146 SCL-1 1
12 PC9 86 57 H3255 12 102 Capan1 3 147 SNB-75 1
13 MDA-MB-453 78 58 LXFL 12 103 H358 4 148 SW1736 1
14 HUVEC 79 59 MiaPaCa-2 12 104 H460 5 149 THP-1 1
15 H1975 122 60 OVXF 12 105 MDA231 3 150 TK-10 1
16 MK 91 61 SXF 12 106 MDA468 3 151 ZR-75-30 1
17 HCC827 62 62 A498 10 107 MDA-MB-175 3 152 Ba/F3 93
18 DiFi 56 63 B16-F10 10 108 NCI-H1781 3 153 HT29 o rA2780 48
19 HFF 52 64 Delfia 9 109 KPL-4 2 154 HUVEC or NIH3T3 43
20 HCT116 49 65 HS27 9 110 Clone24 2 155 Balb/c3T3 3
21 HeLa 51 66 MDA-MB-435 9 111 JIMT-1 2 156 NIH3T3/neu 3
22 3T3 45 67 RAVSMC 9 112 L1210 2 157 PC9/ZD 2
23 HGF-7 41 68 U87MG 9 113 LOVO 7 158 pCMV/Lx-1 2
24 F10 38 69 H1781 9 114 MDA-MB-361 2 159 pTet-On/Lx-1 2
25 MDA-MB-468 33 70 GXA 6 115 P388 2 160 3T3/neu 1
26 CXF 30 71 GXF 6 116 u937 2 161 MCF-7/adr 1
27 HT29 31 72 H1666 6 117 8505C 1 162 95D 1
28 KB2 28 73 H1819 6 118 ACHN 1 163 Bel-7402 1
29 NCI-H1975 62 74 HCC827 GR 6 119 AU565 1 164 BGC-823 1
30 HL7702 28 75 HEPM 6 120 B16F1 1 165 BNL 3
31 HER14 24 76 HN11 6 121 BT20 1 166 Fadu 1
32 MDA-MB-231 25 77 HNXF 6 122 BT549 1 167 H1299 1
33 PRXF 24 78 LIXF 6 123 C4i 1 168 H292 1
34 BALBNK 23 79 LXF 6 124 C643 1 169 HCT8 1
35 A2780 21 80 NCI1975 6 125 CF-7 1
36 SNU638 21 81 PC9 GR 6 126 DU145 1
37 A16-F10 40 82 UXF 6 127 EKVX 1
38 BXF 18 83 MiaPaCa 5 128 GEO 1
39 K562 18 84 T47D 5 129 HCC1419 1
40 LXFA 18 85 AGS 4 130 HCC1937 1
41 MAXF 18 86 Hep3B2 4 131 HCC1954 1
42 MEXF 18 87 MDA175 4 132 HCC202 1
43 PAXF 18 88 NCI-H358 4 133 HCC38 1
44 PXF 18 89 NCI-N87 4 134 HOP-92 1
45 RXF 18 90 Sk-Hep-1 4 135 Hs578t 1
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