Epidermal Growth Factor Receptor Inhibitor Database
Activity against kinases |
Molecule Id: EGIN0005152 |
S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
1 | RET | irreversible inhibitor | 347 ± 101 nM | - | - | - | - | - | - | - |
2 | RON | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
3 | ABL | irreversible inhibitor | 566 ± 222 nM | - | - | - | - | - | - | - |
4 | Flt-1 | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
5 | KDR | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
6 | c-Kit | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
7 | PDGFR-a | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
8 | PDGFR-b | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
9 | EPH-A2 | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
10 | IGF1R | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
11 | FGFR1 | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |