Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0005148 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | RET | irreversible inhibitor | 223 ± 64 nM | - | - | - | - | - | - | - |
| 2 | RON | irreversible inhibitor | 6097 ± 5189 nM | - | - | - | - | - | - | - |
| 3 | ABL | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
| 4 | Flt-1 | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
| 5 | KDR | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
| 6 | c-Kit | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
| 7 | PDGFR-a | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
| 8 | PDGFR-b | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
| 9 | EPH-A2 | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
| 10 | IGF1R | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
| 11 | FGFR1 | irreversible inhibitor | 10000 nM | - | - | - | - | - | - | - |
