Epidermal Growth Factor Receptor Inhibitor Database


Activity against kinases
Molecule Id: EGIN0004537
S.No. Kinase Mutant IC50 Ki Kd Enz. inhib. (%) Inhib. Conc. Cellular IC50 Cell line Growth Factor
1MEK1-1100 nM-------
2MEK5-5700 nM-------
3c-Met-4200 nM-------
4Aurora B-1700 nM-------
5VEGFR 1->10000 nM-------
6VEGFR 2->10000 nM-------
7FGFR1->10000 nM-------
8FGFR 3->10000 nM-------
9PDGFR a->10000 nM-------
10PDGFR ß->10000 nM-------
11IRK->10000 nM-------
12TIE2->10000 nM-------
13c-kit->10000 nM-------
14IGF-1R->10000 nM-------
15Src->10000 nM-------
16Lck-2400 nM-------
17CSK-4700 nM-------
18FAK->10000 nM-------
19Lyn A->10000 nM-------
20Lyn B-5200 nM-------
21ASK 1->10000 nM-------
22TAK 1->10000 nM-------
23MEKK 1->10000 nM-------
24IKK bata->10000 nM-------
25JNK 1->10000 nM-------
26ERK 1->10000 nM-------
27P38 alpha->10000 nM-------
28PKA->10000 nM-------
29PKC thete->10000 nM-------
30GSK3 beta->10000 nM-------
31B-raf->10000 nM-------
32TTK->10000 nM-------
33PLK 1->10000 nM-------