Epidermal Growth Factor Receptor Inhibitor Database


Activity against kinases
Molecule Id: EGIN0004373
S.No. Kinase Mutant IC50 Ki Kd Enz. inhib. (%) Inhib. Conc. Cellular IC50 Cell line Growth Factor
1P110alpha-0.035 ± 0.017 nM-------
2P110beta-0.175 ± 0.067 nM-------
3P110gamma-0.348 ± 0.013 nM-------
4P110delta-0.108 ± 0.048 nM-------
5P110alpha H1047R-0.058 ± 0.002 nM-------
6P110a E545K-0.099 ± 0.006 nM-------
7P110a E542K-0.084 ± 0.001 nM-------
8Protein kinases Fak->10 nM-------
9KDR->10 nM-------
10PKA->10 nM-------
11PKB->10 nM-------
12PDK1->10 nM-------
13HER-1->10 nM-------
14c-Met->10 nM-------
15IGF1->10 nM-------
16Eph-B4->10 nM-------
17FGFR3->10 nM-------
18Ret->10 nM-------
19Tek->10 nM-------
20B-Raf V599E-9.2 nM-------
21c-Abl->10 nM-------
22c-Src->10 nM-------
23Jak-2->10 nM-------
24mTOR-4.6 ± 1.86 nM-------