Epidermal Growth Factor Receptor Inhibitor Database


Activity against kinases
Molecule Id: EGIN0004340
S.No. Kinase Mutant IC50 Ki Kd Enz. inhib. (%) Inhib. Conc. Cellular IC50 Cell line Growth Factor
1Lck%ACTIVITY RELATIVE TO 100%DMSO---310 µM---
2YES1%ACTIVITY RELATIVE TO 100%DMSO---710 µM---
3PHK%ACTIVITY RELATIVE TO 100%DMSO---1010 µM---
4RIPK2%ACTIVITY RELATIVE TO 100%DMSO---1010 µM---
5PIM1%ACTIVITY RELATIVE TO 100%DMSO---1210 µM---
6MNK2%ACTIVITY RELATIVE TO 100%DMSO---1410 µM---
7EPH-B3%ACTIVITY RELATIVE TO 100%DMSO---1710 µM---
8PKD1%ACTIVITY RELATIVE TO 100%DMSO---1810 µM---
9SmMLCK%ACTIVITY RELATIVE TO 100%DMSO---1810 µM---
10AuroraB%ACTIVITY RELATIVE TO 100%DMSO---2110 µM---
11DYRK3%ACTIVITY RELATIVE TO 100%DMSO---2710 µM---
12BRSK2%ACTIVITY RELATIVE TO 100%DMSO---2910 µM---
13MKK1%ACTIVITY RELATIVE TO 100%DMSO---2910 µM---
14PIM3%ACTIVITY RELATIVE TO 100%DMSO---3210 µM---
15MINK1%ACTIVITY RELATIVE TO 100%DMSO---3510 µM---
16FGF-R1%ACTIVITY RELATIVE TO 100%DMSO---3710 µM---
17PRK2%ACTIVITY RELATIVE TO 100%DMSO---3710 µM---
18CHK2%ACTIVITY RELATIVE TO 100%DMSO---3810 µM---
19NUAK1%ACTIVITY RELATIVE TO 100%DMSO---3910 µM---
20Src%ACTIVITY RELATIVE TO 100%DMSO---4410 µM---
21GCK%ACTIVITY RELATIVE TO 100%DMSO---4810 µM---
22MELK%ACTIVITY RELATIVE TO 100%DMSO---4910 µM---
23MetNK1%ACTIVITY RELATIVE TO 100%DMSO---4910 µM---
24VEGFR%ACTIVITY RELATIVE TO 100%DMSO---5010 µM---
25DYRK2%ACTIVITY RELATIVE TO 100%DMSO---5110 µM---
26BRSK1%ACTIVITY RELATIVE TO 100%DMSO---5210 µM---
27EPH-A2%ACTIVITY RELATIVE TO 100%DMSO---5310 µM---
28CAMK1%ACTIVITY RELATIVE TO 100%DMSO---5710 µM---
29PIM2%ACTIVITY RELATIVE TO 100%DMSO---6210 µM---
30CSK%ACTIVITY RELATIVE TO 100%DMSO---6310 µM---
31p38a%ACTIVITY RELATIVE TO 100%DMSO---6310 µM---
32AMPK%ACTIVITY RELATIVE TO 100%DMSO---6510 µM---
33DYRK1A%ACTIVITY RELATIVE TO 100%DMSO---6510 µM---
34MLK3%ACTIVITY RELATIVE TO 100%DMSO---6510 µM---
35AuroraA%ACTIVITY RELATIVE TO 100%DMSO---6610 µM---
36CAMKKb%ACTIVITY RELATIVE TO 100%DMSO---6610 µM---
37CK1%ACTIVITY RELATIVE TO 100%DMSO---6610 µM---
38SYK%ACTIVITY RELATIVE TO 100%DMSO---6710 µM---
39ERK1%ACTIVITY RELATIVE TO 100%DMSO---7010 µM---
40IRR%ACTIVITY RELATIVE TO 100%DMSO---7010 µM---
41PKCa%ACTIVITY RELATIVE TO 100%DMSO---7210 µM---
42RSK1%ACTIVITY RELATIVE TO 100%DMSO---7210 µM---
43MARK4%ACTIVITY RELATIVE TO 100%DMSO---7410 µM---
44PAK2%ACTIVITY RELATIVE TO 100%DMSO---7510 µM---
45S6K1%ACTIVITY RELATIVE TO 100%DMSO---7510 µM---
46TBK1%ACTIVITY RELATIVE TO 100%DMSO---7510 µM---
47JNK1%ACTIVITY RELATIVE TO 100%DMSO---7610 µM---
48JNK2%ACTIVITY RELATIVE TO 100%DMSO---7710 µM---
49NEK6%ACTIVITY RELATIVE TO 100%DMSO---7710 µM---
50ERK8%ACTIVITY RELATIVE TO 100%DMSO---7810 µM---
51MST2%ACTIVITY RELATIVE TO 100%DMSO---7810 µM---
52RSK2%ACTIVITY RELATIVE TO 100%DMSO---7810 µM---
53BTK%ACTIVITY RELATIVE TO 100%DMSO---7910 µM---
54CHK1%ACTIVITY RELATIVE TO 100%DMSO---7910 µM---
55IR-HIS%ACTIVITY RELATIVE TO 100%DMSO---7910 µM---
56p38d%ACTIVITY RELATIVE TO 100%DMSO---7910 µM---
57PAK6%ACTIVITY RELATIVE TO 100%DMSO---7910 µM---
58JNK3%ACTIVITY RELATIVE TO 100%DMSO---8010 µM---
59PKBb%ACTIVITY RELATIVE TO 100%DMSO---8010 µM---
60IRAK4%ACTIVITY RELATIVE TO 100%DMSO---8110 µM---
61MAPKAP-K3%ACTIVITY RELATIVE TO 100%DMSO---8110 µM---
62p38b%ACTIVITY RELATIVE TO 100%DMSO---8110 µM---
63MARK2%ACTIVITY RELATIVE TO 100%DMSO---8210 µM---
64PAK4%ACTIVITY RELATIVE TO 100%DMSO---8310 µM---
65PAK5%ACTIVITY RELATIVE TO 100%DMSO---8410 µM---
66p38g%ACTIVITY RELATIVE TO 100%DMSO---8510 µM---
67MARK3%ACTIVITY RELATIVE TO 100%DMSO---8610 µM---
68PKCz%ACTIVITY RELATIVE TO 100%DMSO---8610 µM---
69TTK%ACTIVITY RELATIVE TO 100%DMSO---8610 µM---
70MLK1%ACTIVITY RELATIVE TO 100%DMSO---8710 µM---
71SRPK1%ACTIVITY RELATIVE TO 100%DMSO---8710 µM---
72ERK2%ACTIVITY RELATIVE TO 100%DMSO---8810 µM---
73MST4%ACTIVITY RELATIVE TO 100%DMSO---8810 µM---
74PDK1%ACTIVITY RELATIVE TO 100%DMSO---8810 µM---
75IKKe%ACTIVITY RELATIVE TO 100%DMSO---8910 µM---
76PRAK%ACTIVITY RELATIVE TO 100%DMSO---8910 µM---
77IKKB%ACTIVITY RELATIVE TO 100%DMSO---9010 µM---
78MAPKAP-K2%ACTIVITY RELATIVE TO 100%DMSO---9010 µM---
79EF2K%ACTIVITY RELATIVE TO 100%DMSO---9110 µM---
80PKA%ACTIVITY RELATIVE TO 100%DMSO---9110 µM---
81CDK2-CycA%ACTIVITY RELATIVE TO 100%DMSO---9310 µM---
82MSK1%ACTIVITY RELATIVE TO 100%DMSO---9310 µM---
83SGK1%ACTIVITY RELATIVE TO 100%DMSO---9310 µM---
84PLK1%ACTIVITY RELATIVE TO 100%DMSO---9510 µM---
85ROCK2%ACTIVITY RELATIVE TO 100%DMSO---9510 µM---
86CK2%ACTIVITY RELATIVE TO 100%DMSO---9610 µM---
87GSK3b%ACTIVITY RELATIVE TO 100%DMSO---9610 µM---
88HIPK2%ACTIVITY RELATIVE TO 100%DMSO---9710 µM---
89NEK2a%ACTIVITY RELATIVE TO 100%DMSO---9710 µM---
90LKB1%ACTIVITY RELATIVE TO 100%DMSO---10310 µM---
91PKBa%ACTIVITY RELATIVE TO 100%DMSO---10310 µM---
92IGF-1R%ACTIVITY RELATIVE TO 100%DMSO---10510 µM---
93HIPK3%ACTIVITY RELATIVE TO 100%DMSO---10610 µM---
94HIPK1%ACTIVITY RELATIVE TO 100%DMSO---12610 µM---