Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004197 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | Akt1/PKB alpha | - | >10000000nM | - | - | - | - | - | - | - |
| 2 | Alk | - | >10000000nM | - | - | - | - | - | - | - |
| 3 | Btk | - | >10000000nM | - | - | - | - | - | - | - |
| 4 | EphB4 | - | >10000000nM | - | - | - | - | - | - | - |
| 5 | Hck | - | >10000000nM | - | - | - | - | - | - | - |
| 6 | IGF1R | - | >10000000nM | - | - | - | - | - | - | - |
| 7 | InsR | - | >10000000nM | - | - | - | - | - | - | - |
| 8 | JAK2 | - | >10000000nM | - | - | - | - | - | - | - |
| 9 | JNK1-3 | - | >10000000nM | - | - | - | - | - | - | - |
| 10 | Kit | - | >10000000nM | - | - | - | - | - | - | - |
| 11 | Lck | - | >10000000nM | - | - | - | - | - | - | - |
| 12 | Met | - | >10000000nM | - | - | - | - | - | - | - |
| 13 | p38a-MAP | - | >10000000nM | - | - | - | - | - | - | - |
| 14 | PAK2 | - | >10000000nM | - | - | - | - | - | - | - |
| 15 | PI3 kinase | - | >10000000nM | - | - | - | - | - | - | - |
| 16 | Ret | - | >10000000nM | - | - | - | - | - | - | - |
| 17 | ROCK-I/II | - | >10000000nM | - | - | - | - | - | - | - |
| 18 | Syk | - | >10000000nM | - | - | - | - | - | - | - |
| 19 | Zap70 | - | >10000000nM | - | - | - | - | - | - | - |
| 20 | JAK3 | - | 1500000nM | - | - | - | - | - | - | - |
| 21 | CDK2/cyclinA | - | 2300000nM | - | - | - | - | - | - | - |
| 22 | Abl | - | 3300000nM | - | - | - | - | - | - | - |
| 23 | PKA | - | 3400000nM | - | - | - | - | - | - | - |
| 24 | KDR | - | 3900000nM | - | - | - | - | - | - | - |
| 25 | Flt4 | - | 4600000nM | - | - | - | - | - | - | - |
| 26 | Fyn | - | 5500000nM | - | - | - | - | - | - | - |
| 27 | PDK1 | - | 6700000nM | - | - | - | - | - | - | - |
| 28 | JAK1 | - | 7300000nM | - | - | - | - | - | - | - |
| 29 | FAK | - | 8300000nM | - | - | - | - | - | - | - |
| 30 | GSK-3 beta | - | 870000nM | - | - | - | - | - | - | - |
| 31 | Axl | - | 9100000nM | - | - | - | - | - | - | - |
