Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004170 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | Aurora A | - | 3 µg/mL | - | - | - | - | - | - | - |
| 2 | Aurora B | - | 1.8 µg/mL | - | - | - | - | - | - | - |
| 3 | CDK4/CycD1 | - | 3.6 µg/mL | - | - | - | - | - | - | - |
| 4 | COT | - | 7.3 µg/mL | - | - | - | - | - | - | - |
| 5 | FLT3 | - | 2.5 µg/mL | - | - | - | - | - | - | - |
| 6 | IGF1R | - | 2.8 µg/mL | - | - | - | - | - | - | - |
| 7 | InsR | - | 3.9 µg/mL | - | - | - | - | - | - | - |
| 8 | MET | - | 4.3 µg/mL | - | - | - | - | - | - | - |
| 9 | SAK | - | 4.4 µg/mL | - | - | - | - | - | - | - |
| 10 | SRC | - | 1.8 µg/mL | - | - | - | - | - | - | - |
| 11 | TIE2 | - | 4.5 µg/mL | - | - | - | - | - | - | - |
| 12 | VEGFR2 | - | 1.2 µg/mL | - | - | - | - | - | - | - |
| 13 | VEGFR3 | - | 2.7 µg/mL | - | - | - | - | - | - | - |
