Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004152 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | CDKs | - | >10000 nM | - | - | - | - | - | - | - |
| 2 | CHK1/2 | - | >10000 nM | - | - | - | - | - | - | - |
| 3 | DLK | - | >3000 nM | - | - | - | - | - | - | - |
| 4 | EGFR | - | >10000 nM | - | - | - | - | - | - | - |
| 5 | FGFR1 | - | >10000 nM | - | - | - | - | - | - | - |
| 6 | Fyn | - | 1190nM | - | - | - | - | - | - | - |
| 7 | IRK | - | >10000 nM | - | - | - | - | - | - | - |
| 8 | JNK | - | >30000 nM | - | - | - | - | - | - | - |
| 9 | Lck | - | >10000 nM | - | - | - | - | - | - | - |
| 10 | MKK4/7 | - | >3000 nM | - | - | - | - | - | - | - |
| 11 | MLK1 | - | 26 ± 12 nM | - | - | - | - | - | - | - |
| 12 | MLK2 | - | 1855 ± 87 nM | - | - | - | - | - | - | - |
| 13 | MLK3 | - | 65 ± 9 nM | - | - | - | - | - | - | - |
| 14 | P38R | - | >10000 nM | - | - | - | - | - | - | - |
| 15 | PDGFR | - | >10000 nM | - | - | - | - | - | - | - |
| 16 | PKC | - | >6000 nM | - | - | - | - | - | - | - |
| 17 | TrkA | - | 1055 ± 224 nM | - | - | - | - | - | - | - |
| 18 | VEGFR1 | - | >10000 nM | - | - | - | - | - | - | - |
| 19 | VEGFR2 | - | 3378 ± 585 nM | - | - | - | - | - | - | - |
| 20 | VEGFR3 | - | 2459 ± 569 nM | - | - | - | - | - | - | - |
