Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004117 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | ARK5 | - | 9.5X10-7 g/mL | - | - | - | - | - | - | - |
| 2 | Aurora A | - | 7.3X10-7 g/mL | - | - | - | - | - | - | - |
| 3 | Aurora B | - | 4.2X10-7 g/mL | - | - | - | - | - | - | - |
| 4 | B-RAF-VE | - | 1.6X10-6 g/mL | - | - | - | - | - | - | - |
| 5 | CDK2/CycA | - | 3.3X10-6 g/mL | - | - | - | - | - | - | - |
| 6 | CDK4/CycD1 | - | 2.4X10-6 g/mL | - | - | - | - | - | - | - |
| 7 | CK2 alpha1 | - | 2.0X10-6 g/mL | - | - | - | - | - | - | - |
| 8 | COT | - | 8.0X10-6 g/mL | - | - | - | - | - | - | - |
| 9 | FAK | - | 2.4X10-6 g/mL | - | - | - | - | - | - | - |
| 10 | FLT3 | - | 4.3X10-7 g/mL | - | - | - | - | - | - | - |
| 11 | IGF1R | - | 3.4X10-6 g/mL | - | - | - | - | - | - | - |
| 12 | InsR | - | 2.1X10-6 g/mL | - | - | - | - | - | - | - |
| 13 | MET | - | 5.4X10-6 g/mL | - | - | - | - | - | - | - |
| 14 | PDGFR beta | - | 8.9X10-7 g/mL | - | - | - | - | - | - | - |
| 15 | PLK1 | - | 6.9X10-6 g/mL | - | - | - | - | - | - | - |
| 16 | SAK | - | 9.6X10-7 g/mL | - | - | - | - | - | - | - |
| 17 | SRC | - | 4.4X10-6 g/mL | - | - | - | - | - | - | - |
| 18 | TIE2 | - | 7.0X10-6 g/mL | - | - | - | - | - | - | - |
| 19 | VEGFR2 | - | 9.2X10-7 g/mL | - | - | - | - | - | - | - |
| 20 | VEGFR3 | - | 1.3X10-6 g/mL | - | - | - | - | - | - | - |
