Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004116 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | BTK | - | >10000nM | - | - | - | - | - | - | - |
| 2 | EGFR | - | >10000nM | - | - | - | - | - | - | - |
| 3 | GSK-3 | - | >10000nM | - | - | - | - | - | - | - |
| 4 | IGFR | - | >10000nM | - | - | - | - | - | - | - |
| 5 | IKK | - | >10000nM | - | - | - | - | - | - | - |
| 6 | KDR | - | >10000nM | - | - | - | - | - | - | - |
| 7 | MEK1 | - | >10000nM | - | - | - | - | - | - | - |
| 8 | MK2 | - | >200000nM | - | - | - | - | - | - | - |
| 9 | PDK1 | - | >200000nM | - | - | - | - | - | - | - |
| 10 | AKT1 | - | >30000nM | - | - | - | - | - | - | - |
| 11 | LCK | - | >30000nM | - | - | - | - | - | - | - |
| 12 | LYN | - | >30000nM | - | - | - | - | - | - | - |
| 13 | S6K1 | - | >30000nM | - | - | - | - | - | - | - |
| 14 | Tpl2 | - | >40000nM | - | - | - | - | - | - | - |
| 15 | CDK4 | - | >50000nM | - | - | - | - | - | - | - |
| 16 | PI3K delta | - | 11nM | - | - | - | - | - | - | - |
| 17 | PI3K alpha | - | 1110nM | - | - | - | - | - | - | - |
| 18 | PI3K beta | - | 13nM | - | - | - | - | - | - | - |
| 19 | mTOR | - | 28600nM | - | - | - | - | - | - | - |
| 20 | PI3K gamma | - | 8nM | - | - | - | - | - | - | - |
