Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004028 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | Casein kinase 2 | - | >100000nM | - | - | - | - | - | - | - |
| 2 | PKC alpha/gamma | - | >100000nM | - | - | - | - | - | - | - |
| 3 | PKC beta2 | - | >100000nM | - | - | - | - | - | - | - |
| 4 | CDK2/cyclinA | - | 0.4nM | - | - | - | - | - | - | - |
| 5 | calmodulin kinase | - | 10500nM | - | - | - | - | - | - | - |
| 6 | CDK4/cyclinD1 | - | 120nM | - | - | - | - | - | - | - |
| 7 | FGFR2 | - | 180nM | - | - | - | - | - | - | - |
| 8 | insulin kinase beta | - | 2400nM | - | - | - | - | - | - | - |
| 9 | GSK-3 | - | 26nM | - | - | - | - | - | - | - |
| 10 | PDGFR beta | - | 310nM | - | - | - | - | - | - | - |
| 11 | CDK1/cyclinB | - | 4.8nM | - | - | - | - | - | - | - |
| 12 | PKA | - | 4300nM | - | - | - | - | - | - | - |
| 13 | VEGFR2 | - | 51nM | - | - | - | - | - | - | - |
| 14 | Casein kinase 1 | - | 570nM | - | - | - | - | - | - | - |
| 15 | MAP kinase/ERK2 | - | 5900nM | - | - | - | - | - | - | - |
