Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0004027 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | calmodulin kinase | - | >100000nM | - | - | - | - | - | - | - |
| 2 | Casein Kinase 1 | - | >100000nM | - | - | - | - | - | - | - |
| 3 | casein kinase 2 | - | >100000nM | - | - | - | - | - | - | - |
| 4 | PKA | - | >100000nM | - | - | - | - | - | - | - |
| 5 | PKC alpha/gamma | - | >100000nM | - | - | - | - | - | - | - |
| 6 | PKC beta2 | - | >100000nM | - | - | - | - | - | - | - |
| 7 | CDK2/cyclinA | - | 0.3nM | - | - | - | - | - | - | - |
| 8 | PDGFR beta | - | 10700nM | - | - | - | - | - | - | - |
| 9 | CDK4/cyclinD1 | - | 190nM | - | - | - | - | - | - | - |
| 10 | FGFR2 | - | 270nM | - | - | - | - | - | - | - |
| 11 | CDK1/cyclinB | - | 3nM | - | - | - | - | - | - | - |
| 12 | GSK-3 | - | 31nM | - | - | - | - | - | - | - |
| 13 | VEGFR2 | - | 510nM | - | - | - | - | - | - | - |
| 14 | MAP kinase/ERK2 | - | 9500nM | - | - | - | - | - | - | - |
| 15 | insulin kinase beta | - | 9800nM | - | - | - | - | - | - | - |
