Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0003438 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | CDK1 | - | >40 nM | - | - | - | - | - | - | - |
| 2 | CDK5p25 | - | >40 nM | - | - | - | - | - | - | - |
| 3 | cFMS | - | 0.08nM | - | - | - | - | - | - | - |
| 4 | c-Kit | - | 0.03nM | - | - | - | - | - | - | - |
| 5 | c-Met | - | 13.7nM | - | - | - | - | - | - | - |
| 6 | E2K2 | - | >40 nM | - | - | - | - | - | - | - |
| 7 | FGF | - | 4.37nM | - | - | - | - | - | - | - |
| 8 | GSK-3 beta | - | >40 nM | - | - | - | - | - | - | - |
| 9 | IGFR1 | - | 4.01nM | - | - | - | - | - | - | - |
| 10 | JNK1 | - | >40 nM | - | - | - | - | - | - | - |
| 11 | JNK2 | - | >40 nM | - | - | - | - | - | - | - |
| 12 | JNK3 | - | >40 nM | - | - | - | - | - | - | - |
| 13 | KDR | - | 0.005nM | - | - | - | - | - | - | - |
| 14 | LCK | - | 1.14nM | - | - | - | - | - | - | - |
| 15 | p38 alpha | - | >40 nM | - | - | - | - | - | - | - |
| 16 | p38 beta | - | >40 nM | - | - | - | - | - | - | - |
| 17 | Src | - | 0.72nM | - | - | - | - | - | - | - |
| 18 | TIE2 | - | 3.18nM | - | - | - | - | - | - | - |
| 19 | Zap70 | - | >25 nM | - | - | - | - | - | - | - |
