Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0003404 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | calmodulin kinase 2 | - | >10000nM | - | - | - | - | - | - | - |
| 2 | Casein kinase 2 | - | >10000nM | - | - | - | - | - | - | - |
| 3 | FGFR-2 | - | >10000nM | - | - | - | - | - | - | - |
| 4 | Insulin R kinase | - | >10000nM | - | - | - | - | - | - | - |
| 5 | MAPK/ERK2 | - | >10000nM | - | - | - | - | - | - | - |
| 6 | PDGFR | - | >10000nM | - | - | - | - | - | - | - |
| 7 | PKA | - | >10000nM | - | - | - | - | - | - | - |
| 8 | PKB beta | - | >10000nM | - | - | - | - | - | - | - |
| 9 | PKC gamma | - | >10000nM | - | - | - | - | - | - | - |
| 10 | CDK7/cyclinH | - | 126nM | - | - | - | - | - | - | - |
| 11 | GSK-3 beta | - | 20 ± 4nM | - | - | - | - | - | - | - |
| 12 | CDK1/cyclinB | - | 21 ± 6nM | - | - | - | - | - | - | - |
| 13 | CDK5/p35 | - | 3nM | - | - | - | - | - | - | - |
| 14 | Casein kinase 1 | - | 3050 ± 1500nM | - | - | - | - | - | - | - |
| 15 | CDK4/cyclinD1 | - | 308 ± 54nM | - | - | - | - | - | - | - |
| 16 | VEGFR2 | - | 3500 ± 1320nM | - | - | - | - | - | - | - |
| 17 | CDK6/cyclinD3 | - | 356nM | - | - | - | - | - | - | - |
| 18 | CDK2/cyclinA | - | 7 ± 2nM | - | - | - | - | - | - | - |
