Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0003305 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | Blk | - | 27nM | - | - | - | - | - | - | - |
| 2 | CDK | - | >10000 nM | - | - | - | - | - | - | - |
| 3 | Fgr | - | 2.8nM | - | - | - | - | - | - | - |
| 4 | Fyn | - | 5nM | - | - | - | - | - | - | - |
| 5 | Hck | - | 23nM | - | - | - | - | - | - | - |
| 6 | HER1 | - | >1000 nM | - | - | - | - | - | - | - |
| 7 | HER2 | - | >1000 nM | - | - | - | - | - | - | - |
| 8 | IKK1 | - | >10000 nM | - | - | - | - | - | - | - |
| 9 | IKK2 | - | >10000 nM | - | - | - | - | - | - | - |
| 10 | Lck | - | 4nM | - | - | - | - | - | - | - |
| 11 | Lyn | - | 0.5nM | - | - | - | - | - | - | - |
| 12 | p38 | - | 380nM | - | - | - | - | - | - | - |
| 13 | PDGFR | - | >1000 nM | - | - | - | - | - | - | - |
| 14 | PKA | - | >10000 nM | - | - | - | - | - | - | - |
| 15 | PKC | - | >10000 nM | - | - | - | - | - | - | - |
| 16 | Src | - | 4nM | - | - | - | - | - | - | - |
| 17 | Syk | - | >10000 nM | - | - | - | - | - | - | - |
| 18 | VEGFR | - | >1000 nM | - | - | - | - | - | - | - |
| 19 | Yes | - | 4.7nM | - | - | - | - | - | - | - |
| 20 | Zap70 | - | >1000 nM | - | - | - | - | - | - | - |
| 21 | Lck | - | - | 0.55 ± 0.04 nM | - | - | - | - | - | - |
| 22 | Lck | - | - | - | 0.17 ± 0.03 nM | - | - | - | - | - |
