Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0003295 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | ABL | - | >10000 nM | - | - | - | - | - | - | - |
| 2 | AKT1 | - | >10000 nM | - | - | - | - | - | - | - |
| 3 | Aur2 | - | >10000 nM | - | - | - | - | - | - | - |
| 4 | CDC7/DBF4 | - | >10000 nM | - | - | - | - | - | - | - |
| 5 | CDK1/cyclinB | - | 270nM | - | - | - | - | - | - | - |
| 6 | CDK2/cyclinA | - | 37nM | - | - | - | - | - | - | - |
| 7 | CDK2/cyclinE | - | 92nM | - | - | - | - | - | - | - |
| 8 | CDK4/cyclinD1 | - | >10000 nM | - | - | - | - | - | - | - |
| 9 | CDK5/p25 | - | 114nM | - | - | - | - | - | - | - |
| 10 | CHK1 | - | >10000 nM | - | - | - | - | - | - | - |
| 11 | CK2 | - | >10000 nM | - | - | - | - | - | - | - |
| 12 | EGFR-1 | - | >10000 nM | - | - | - | - | - | - | - |
| 13 | ERK2 | - | 4600nM | - | - | - | - | - | - | - |
| 14 | FGFR1 | - | >10000 nM | - | - | - | - | - | - | - |
| 15 | GSK-3 beta | - | 1905nM | - | - | - | - | - | - | - |
| 16 | IGFR1 | - | >10000 nM | - | - | - | - | - | - | - |
| 17 | IKK-2 | - | >10000 nM | - | - | - | - | - | - | - |
| 18 | IKKi | - | >10000 nM | - | - | - | - | - | - | - |
| 19 | IR | - | >10000 nM | - | - | - | - | - | - | - |
| 20 | KIT | - | >10000 nM | - | - | - | - | - | - | - |
| 21 | LCK | - | >10000 nM | - | - | - | - | - | - | - |
| 22 | LYN | - | >10000 nM | - | - | - | - | - | - | - |
| 23 | MET | - | >10000 nM | - | - | - | - | - | - | - |
| 24 | p38R | - | >10000 nM | - | - | - | - | - | - | - |
| 25 | PAK4 | - | >10000 nM | - | - | - | - | - | - | - |
| 26 | PDGFR-1 | - | >10000 nM | - | - | - | - | - | - | - |
| 27 | PDK1 | - | >10000 nM | - | - | - | - | - | - | - |
| 28 | PKC beta | - | >10000 nM | - | - | - | - | - | - | - |
| 29 | PLK1 | - | >10000 nM | - | - | - | - | - | - | - |
| 30 | RET | - | >10000 nM | - | - | - | - | - | - | - |
| 31 | STLK2 | - | >10000 nM | - | - | - | - | - | - | - |
| 32 | TRKA | - | >10000 nM | - | - | - | - | - | - | - |
| 33 | VEGFR2 | - | >10000 nM | - | - | - | - | - | - | - |
| 34 | VEGFR3 | - | >10000 nM | - | - | - | - | - | - | - |
| 35 | ZAP70 | - | >10000 nM | - | - | - | - | - | - | - |
