Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0003272 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | c-Abl | - | 5330 ± 70 nM | - | - | - | - | - | - | - |
| 2 | CDK1 | - | >10000 nM | - | - | - | - | - | - | - |
| 3 | c-Kit | - | 105 ± 40 nM | - | - | - | - | - | - | - |
| 4 | c-Met | - | >10000 nM | - | - | - | - | - | - | - |
| 5 | CSF1R | - | 99 ± 21 nM | - | - | - | - | - | - | - |
| 6 | c-Src | - | >10000 nM | - | - | - | - | - | - | - |
| 7 | FGFR1 | - | 5100 ± 1660 nM | - | - | - | - | - | - | - |
| 8 | IGF1R | - | 6400 ± 200 nM | - | - | - | - | - | - | - |
| 9 | PDGFR beta | - | 357 ± 130 nM | - | - | - | - | - | - | - |
| 10 | TIE2 | - | 6800 ± 2180 nM | - | - | - | - | - | - | - |
| 11 | VEGFR1 | - | 130 ± 30 nM | - | - | - | - | - | - | - |
| 12 | VEGFR2 | - | 9 ± 1 nM | - | - | - | - | - | - | - |
| 13 | VEGFR3 | - | 52 ± 1 nM | - | - | - | - | - | - | - |
