Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0003271 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | c-Abl | - | 2820nM | - | - | - | - | - | - | - |
| 2 | CDK1 | - | >10000 nM | - | - | - | - | - | - | - |
| 3 | c-Kit | - | 236 ± 60 nM | - | - | - | - | - | - | - |
| 4 | c-Met | - | >10000 nM | - | - | - | - | - | - | - |
| 5 | CSF1R | - | 380 ± 140 nM | - | - | - | - | - | - | - |
| 6 | c-Src | - | >10000 nM | - | - | - | - | - | - | - |
| 7 | FGFR1 | - | >10000 nM | - | - | - | - | - | - | - |
| 8 | IGF1R | - | >10000 nM | - | - | - | - | - | - | - |
| 9 | PDGFR beta | - | 640 ± 100 nM | - | - | - | - | - | - | - |
| 10 | TIE2 | - | >10000 nM | - | - | - | - | - | - | - |
| 11 | VEGFR1 | - | 130 ± 81 nM | - | - | - | - | - | - | - |
| 12 | VEGFR2 | - | 23 ± 6 nM | - | - | - | - | - | - | - |
| 13 | VEGFR3 | - | 18 ± 1 nM | - | - | - | - | - | - | - |
