Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0003270 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | CDK1/cyclinB | - | 30nM | - | - | - | - | - | - | - |
| 2 | CDK2/cyclinE | - | 3nM | - | - | - | - | - | - | - |
| 3 | CDK4/cyclinD1 | - | 102nM | - | - | - | - | - | - | - |
| 4 | EMT | - | 29000nM | - | - | - | - | - | - | - |
| 5 | Her1 | - | >25000 nM | - | - | - | - | - | - | - |
| 6 | Her2 | - | >25000 nM | - | - | - | - | - | - | - |
| 7 | IGFR | - | 24000nM | - | - | - | - | - | - | - |
| 8 | IKK | - | 28000nM | - | - | - | - | - | - | - |
| 9 | Lck | - | >40000 nM | - | - | - | - | - | - | - |
| 10 | PKC beta | - | >45000 nM | - | - | - | - | - | - | - |
| 11 | PKC epsilion | - | 5600nM | - | - | - | - | - | - | - |
| 12 | PKC zeta | - | 35000nM | - | - | - | - | - | - | - |
| 13 | PKC zeta | - | 45000nM | - | - | - | - | - | - | - |
| 14 | ZAP70 | - | >50000 nM | - | - | - | - | - | - | - |
