Epidermal Growth Factor Receptor Inhibitor Database


Activity against kinases
Molecule Id: EGIN0003040
S.No. Kinase Mutant IC50 Ki Kd Enz. inhib. (%) Inhib. Conc. Cellular IC50 Cell line Growth Factor
1CDK1->10000 nM-------
2CDK2->10000 nM-------
3CDK2/CYCLINA->10000 nM-------
4CDK4->10000 nM-------
5CHK1->10000 nM-------
6CK1->10000 nM-------
7CK2->10000 nM-------
8CSK->10000 nM-------
9DYRK1A->10000 nM-------
10FGFR1-69 ± 70 nM-------
11FGFR-2-37 ± 2 nM-------
12FGFR3-108 ± 41 nM-------
13FGFR-4-610 ± 117 nM-------
14FLT3-26nM-------
15GSK-3B->10000 nM-------
16HGFR->10000 nM-------
17IGF1R->1000 nM-------
18InsR->4000 nM-------
19JNK1A1->10000 nM-------
20Lck-16 ± 16 nM-------
21Lyn-195 ± 12 nM-------
22MAPK2ERK2->10000 nM-------
23MAPKAPK2->10000 nM-------
24MSK1->10000 nM-------
25PDGFRa-59 ± 71 nM-------
26PDGFRh-65 ± 7 nM-------
27PDK1->10000 nM-------
28PHK->10000 nM-------
29PKA->10000 nM-------
30PKBA->10000 nM-------
31PKCA->10000 nM-------
32PP2A->10000 nM-------
33PRAK->10000 nM-------
34ROCKII->10000 nM-------
35S6K1->10000 nM-------
36SAPK2AP38->10000 nM-------
37SAPK2BP38B2->10000 nM-------
38SAPK3P38G->10000 nM-------
39SAPK4p38 delta->10000 nM-------
40SGK->10000 nM-------
41Src-156 ± 40 nM-------
42VEGFR1-34 ± 15 nM-------
43VEGFR2-21 ± 13 nM-------
44VEGFR2/mouse-13 ± 4 nM-------
45VEGFR3-13 ± 10 nM-------