Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0002477 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | AurolaA | - | 1050nM | - | - | - | - | - | - | - |
| 2 | B-raf | - | 900nM | - | - | - | - | - | - | - |
| 3 | c-kit | - | 170nM | - | - | - | - | - | - | - |
| 4 | ERK1 | - | >10000 nM | - | - | - | - | - | - | - |
| 5 | FAK | - | 2600nM | - | - | - | - | - | - | - |
| 6 | FGFR1 | - | >10000 nM | - | - | - | - | - | - | - |
| 7 | GSK-3 beta | - | >10000 nM | - | - | - | - | - | - | - |
| 8 | IGF1R | - | >10000 nM | - | - | - | - | - | - | - |
| 9 | IR | - | >10000 nM | - | - | - | - | - | - | - |
| 10 | PDGFR beta | - | 96nM | - | - | - | - | - | - | - |
| 11 | PDGFR alpha | - | 35nM | - | - | - | - | - | - | - |
| 12 | PKC theta | - | >10000 nM | - | - | - | - | - | - | - |
| 13 | Src | - | >10000 nM | - | - | - | - | - | - | - |
| 14 | TIE2 | - | 20nM | - | - | - | - | - | - | - |
| 15 | VEGFR1 | - | 15nM | - | - | - | - | - | - | - |
| 16 | VEGFR2 | - | 6.2nM | - | - | - | - | - | - | - |
