Epidermal Growth Factor Receptor Inhibitor Database
| Activity against kinases |
| Molecule Id: EGIN0000412 |
| S.No. |
Kinase |
Mutant |
IC50 |
Ki |
Kd |
Enz. inhib. (%) |
Inhib. Conc. |
Cellular IC50 |
Cell line |
Growth Factor |
| 1 | PDGFR alpha | - | - | - | - | 9260 | 50µM | - | - | - |
| 2 | VEGFR-2 or KDR | - | - | - | - | 9290 | 50µM | - | - | - |
| 3 | VEGFR-1 or FLT1 | - | - | - | - | 9340 | 50µM | - | - | - |
| 4 | ABL-1 | - | - | - | - | 9460 | 50µM | - | - | - |
| 5 | PDGFR beta | - | - | - | - | 9580 | 50µM | - | - | - |
| 6 | PI3K alpha | - | - | - | - | 9700 | 50µM | - | - | - |
| 7 | PDGFR-alpha | - | - | - | - | 92.60% | 50 µM | - | - | - |
| 8 | PDGFR-beta | - | - | - | - | 95.80% | 50 µM | - | - | - |
| 9 | VEGFR-1(FLT1) | - | - | - | - | 93.40% | 50 µM | - | - | - |
| 10 | VEGFR-2(KDR) | - | - | - | - | 92.90% | 50 µM | - | - | - |
| 11 | ABL-1 | - | - | - | - | 94.60% | 50 µM | - | - | - |
| 12 | PI3K-a | - | - | - | - | 97% | 50 µM | - | - | - |
