Epidermal Growth Factor Receptor Inhibitor Database Experimental Information Page

Epidermal Growth Factor Receptor Inhibitor Database

Experimental Information

Enzymatic Activity
Molecule Id	EGIN0004173
PMID	19271717
Assay Used	Enzymatic assay
Experimently Validated	Yes
EGFR (IC₅₀)	4365.1108010625 nM
HER2 (IC₅₀)	6790.17235720833 nM
HER4 (IC₅₀)	-
Mutant L858R (IC₅₀)	-
Mutant T790M (IC₅₀)	-
Double Mutant (IC₅₀)	-
Average ERBB2 and ERBB1 (IC₅₀)	-
Inhibition EGFR (%)	-
Inhibitory Concentration	-
Inhibition HER2 (%)	-
Inhibitory Concentration	-
K_i (EGFR)	-
K_i (HER2)	-
K_i (HER4)	-
K_d (EGFR)	-
K_d (L858R)	-
K_d (T790M)	-
K_d (L858R/T790M)	-
K_d (Other mutation)	-
Note	The paper describes the bioactive metabolites from the Endophytic Fungus S temphylium globuliferum Isolated from Mentha pulegium as anticancerous agent
Extra	-

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Cellular Activity

S.No.

Cell Line

Desp.

IC₅₀

IC₈₀

ED₅₀

GI₅₀

GI₉₀

EC₅₀

K_d

Inhibition (%)

Inhibitory Conc.

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" .$row2['Cell_Line']."

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" .$row2['ED50']."

" .$row2['ED50_CONVERTED']."

" .$row2['GI50_cell_assay']."

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" .$row2['GI90_CELL_ASSAY']."

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" .$row2['KD_CELL_ASSAY']."

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" .$row2['per_Inhibition_Cellular']."

" .$row2['Inhibition_conc3']."

" .$row2['Cell_lines_used']."