Epidermal Growth Factor Receptor Inhibitor Database Experimental Information Page

Epidermal Growth Factor Receptor Inhibitor Database

Experimental Information

Enzymatic Activity
Molecule Id	EGIN0003578
PMID	9240345
Assay Used	Kinase inhibition assay and RAVSMC growth delay assay
Experimently Validated	Yes
EGFR (IC₅₀)	1360 nM
HER2 (IC₅₀)	-
HER4 (IC₅₀)	-
Mutant L858R (IC₅₀)	-
Mutant T790M (IC₅₀)	-
Double Mutant (IC₅₀)	-
Average ERBB2 and ERBB1 (IC₅₀)	-
Inhibition EGFR (%)	-
Inhibitory Concentration	-
Inhibition HER2 (%)	-
Inhibitory Concentration	-
K_i (EGFR)	-
K_i (HER2)	-
K_i (HER4)	-
K_d (EGFR)	-
K_d (L858R)	-
K_d (T790M)	-
K_d (L858R/T790M)	-
K_d (Other mutation)	-
Note	The paper describes the Structure-Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors
Extra	-

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Cellular Activity

S.No.

Cell Line

Desp.

IC₅₀

IC₈₀

ED₅₀

GI₅₀

GI₉₀

EC₅₀

K_d

Inhibition (%)

Inhibitory Conc.

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" .$row2['Cell_Line']."

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" .$row2['ED50']."

" .$row2['ED50_CONVERTED']."

" .$row2['GI50_cell_assay']."

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" .$row2['GI90_CELL_ASSAY']."

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" .$row2['KD_CELL_ASSAY']."

" .$row2['KD_CELL_ASSAY_CONVERTED']."

" .$row2['per_Inhibition_Cellular']."

" .$row2['Inhibition_conc3']."

" .$row2['Cell_lines_used']."