Epidermal Growth Factor Receptor Inhibitor Database Experimental Information Page

Epidermal Growth Factor Receptor Inhibitor Database

Experimental Information

Enzymatic Activity
Molecule Id	EGIN0002138
PMID	18849971
Assay Used	Kinase assays
Experimently Validated	Yes
EGFR (IC₅₀)	7400 nM
HER2 (IC₅₀)	-
HER4 (IC₅₀)	-
Mutant L858R (IC₅₀)	-
Mutant T790M (IC₅₀)	-
Double Mutant (IC₅₀)	-
Average ERBB2 and ERBB1 (IC₅₀)	-
Inhibition EGFR (%)	-
Inhibitory Concentration	-
Inhibition HER2 (%)	-
Inhibitory Concentration	-
K_i (EGFR)	-
K_i (HER2)	-
K_i (HER4)	-
K_d (EGFR)	-
K_d (L858R)	-
K_d (T790M)	-
K_d (L858R/T790M)	-
K_d (Other mutation)	-
Note	The paper describesof small molecules that can potently inhibit both tyrosine kinases and PI3-Ks but we reported only the EGFR activty
Extra	-

'; echo "" ; echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; echo "" ; echo "" ; #echo "" ; echo ''; } if($j%2==0){ echo ''; echo "" ; echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; echo "" ; echo "" ; #echo "" ; echo ''; } $j++; } echo ''; echo ''; echo "" ; echo ''; mysql_free_result($result2); ?>

Cellular Activity

S.No.

Cell Line

Desp.

IC₅₀

IC₈₀

ED₅₀

GI₅₀

GI₉₀

EC₅₀

K_d

Inhibition (%)

Inhibitory Conc.

" .$j."

" .$row2['Cell_Line']."

" .$row2['Cell_line_desc']."

" .$row2['IC50_cell_assay']."

" .$row2['IC50_SIGN']." ".$row2['IC50_CONVERTED']."

" .$row2['IC80_cell_assay']."

" .$row2['IC80_SIGN']." ".$row2['IC80_CONVERTED']."

" .$row2['ED50']."

" .$row2['ED50_CONVERTED']."

" .$row2['GI50_cell_assay']."

" .$row2['GI50_SIGN']." ".$row2['GI50_CONVERTED']."

" .$row2['GI90_CELL_ASSAY']."

" .$row2['EC50_cell_assay']."

" .$row2['EC50_SIGN']." ".$row2['EC50_CONVERTED']."

" .$row2['KD_CELL_ASSAY']."

" .$row2['KD_CELL_ASSAY_CONVERTED']."

" .$row2['per_Inhibition_Cellular']."

" .$row2['Inhibition_conc3']."

" .$row2['Cell_lines_used']."