Epidermal Growth Factor Receptor Inhibitor Database


Experimental Information
  
Enzymatic Activity
Molecule Id EGIN0001855
PMID 16713265
  Assay Used Inhibition of the phosphorylation of peptide substrate polyGAT by EGFR, antiproliferative Cellular assay
  Experimently ValidatedYes
  EGFR (IC50)  -
  HER2 (IC50)  -
  HER4 (IC50)  -
  Mutant L858R (IC50)  -
  Mutant T790M (IC50)  -
  Double Mutant (IC50)  -
  Average ERBB2 and ERBB1 (IC50) -
  Inhibition EGFR (%) 52.80%
  Inhibitory Concentration 10 µM
  Inhibition HER2 (%) -
  Inhibitory Concentration -
  Ki (EGFR)-
  Ki (HER2)-
  Ki (HER4)-
  Kd (EGFR)-
  Kd (L858R)-
  Kd (T790M)-
  Kd (L858R/T790M)-
  Kd (Other mutation)-
  Note 1,5-disubstituted hydantoins were synthesized and evaluated for inhibition of EGFR kinase activity and antiproliferative action.
  Extra -

'; echo "" ; echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; echo "" ; echo "" ; #echo "" ; echo ''; } if($j%2==0){ echo ''; echo "" ; echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; #echo "" ; echo "" ; echo "" ; echo "" ; #echo "" ; echo ''; } $j++; } echo ''; echo ''; echo "" ; echo ''; mysql_free_result($result2); ?>
Cellular Activity
S.No. Cell Line Desp. IC50 IC80 ED50 GI50 GI90 EC50 Kd Inhibition (%) Inhibitory Conc.
" .$j."" .$row2['Cell_Line']."" .$row2['Cell_line_desc']."" .$row2['IC50_cell_assay']."" .$row2['IC50_SIGN']." ".$row2['IC50_CONVERTED']."" .$row2['IC80_cell_assay']."" .$row2['IC80_SIGN']." ".$row2['IC80_CONVERTED']."" .$row2['ED50']."" .$row2['ED50_CONVERTED']."" .$row2['GI50_cell_assay']."" .$row2['GI50_SIGN']." ".$row2['GI50_CONVERTED']."" .$row2['GI90_CELL_ASSAY']."" .$row2['GI90_CELL_ASSAY']."" .$row2['EC50_cell_assay']."" .$row2['EC50_SIGN']." ".$row2['EC50_CONVERTED']."" .$row2['KD_CELL_ASSAY']."" .$row2['KD_CELL_ASSAY_CONVERTED']."" .$row2['per_Inhibition_Cellular']."" .$row2['Inhibition_conc3']."" .$row2['Cell_lines_used']."
" .$j."" .$row2['Cell_Line']."" .$row2['Cell_line_desc']."" .$row2['IC50_cell_assay']."" .$row2['IC50_SIGN']." ".$row2['IC50_CONVERTED']."" .$row2['IC80_cell_assay']."" .$row2['IC80_SIGN']." ".$row2['IC80_CONVERTED']."" .$row2['ED50']."" .$row2['ED50_CONVERTED']."" .$row2['GI50_cell_assay']."" .$row2['GI50_SIGN']." ".$row2['GI50_CONVERTED']."" .$row2['GI90_CELL_ASSAY']."" .$row2['GI90_CELL_ASSAY']."" .$row2['EC50_cell_assay']."" .$row2['EC50_SIGN']." ".$row2['EC50_CONVERTED']."" .$row2['KD_CELL_ASSAY']."" .$row2['KD_CELL_ASSAY_CONVERTED']."" .$row2['per_Inhibition_Cellular']."" .$row2['Inhibition_conc3']."" .$row2['Cell_lines_used']."

Activity against Receptor
  EGFR Yes
  HER2-
  HER4-
  Wild typeYes
  Mutant-

Inhibitor Binding
  EGFR-
  HER2-
  HER4-