Epidermal Growth Factor Receptor Inhibitor Database Experimental Information Page

Epidermal Growth Factor Receptor Inhibitor Database

Experimental Information

Enzymatic Activity
Molecule Id	EGIN0002631
PMID	12190313
Assay Used	In vitro Kinase assay
Experimently Validated	Yes
EGFR (IC₅₀)	6700 nM
HER2 (IC₅₀)	15800 nM
HER4 (IC₅₀)	-
Mutant L858R (IC₅₀)	-
Mutant T790M (IC₅₀)	-
Double Mutant (IC₅₀)	-
Average ERBB2 and ERBB1 (IC₅₀)	-
Inhibition EGFR (%)	-
Inhibitory Concentration	-
Inhibition HER2 (%)	-
Inhibitory Concentration	-
K_i (EGFR)	-
K_i (HER2)	-
K_i (HER4)	-
K_d (EGFR)	-
K_d (L858R)	-
K_d (T790M)	-
K_d (L858R/T790M)	-
K_d (Other mutation)	-
Note	The paper describes the aminothiazole inhibitors of Cyclin-Dependent Kinase 2.
Extra	-

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Cellular Activity

S.No.

Cell Line

Desp.

IC₅₀

IC₈₀

ED₅₀

GI₅₀

GI₉₀

EC₅₀

K_d

Inhibition (%)

Inhibitory Conc.

" .$j."

" .$row2['Cell_Line']."

" .$row2['Cell_line_desc']."

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" .$row2['IC50_SIGN']." ".$row2['IC50_CONVERTED']."

" .$row2['IC80_cell_assay']."

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" .$row2['ED50']."

" .$row2['ED50_CONVERTED']."

" .$row2['GI50_cell_assay']."

" .$row2['GI50_SIGN']." ".$row2['GI50_CONVERTED']."

" .$row2['GI90_CELL_ASSAY']."

" .$row2['EC50_cell_assay']."

" .$row2['EC50_SIGN']." ".$row2['EC50_CONVERTED']."

" .$row2['KD_CELL_ASSAY']."

" .$row2['KD_CELL_ASSAY_CONVERTED']."

" .$row2['per_Inhibition_Cellular']."

" .$row2['Inhibition_conc3']."

" .$row2['Cell_lines_used']."