Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
TP53	ACPGRDRRE	LUNG	276	p.TEE284del	c.850_858delACAGAGGAA	In_Frame_Del	1	0.11	HCC1833	N	0	0	0	N
TP53	AKTCPVQLC	CENTRAL_NERVOUS_SYSTEM	138	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	1	0.11	YKG1	N	1	0	0	N
TP53	ALIRVEGNL	LIVER	189	p.PPQH190del	c.569_580delCTCCTCAGCATC	In_Frame_Del	1	0.11	JHH5	Y	12	16	0	N
TP53	CPGRDRREN	LUNG	277	p.TEE284del	c.850_858delACAGAGGAA	In_Frame_Del	2	0.11	HCC1833	N	3	0	0	N
TP53	CPVQLCTPP	CENTRAL_NERVOUS_SYSTEM	141	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	4	0.11	YKG1	N	0	0	0	N
TP53	CTPPPGTRV	CENTRAL_NERVOUS_SYSTEM	146	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	1	0.11	YKG1	Y	2	9	0	N
TP53	CTTIYNYMC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	229	p.H233del	c.697_699delCAC	In_Frame_Del	3	0.11	MEG01	N	1	0	0	N
TP53	DCTTIYNYM	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	228	p.H233del	c.697_699delCAC	In_Frame_Del	4	0.11	MEG01	Y	2	9	0	Y
TP53	DDRNTFRHV	BONE	207	p.S215del	c.643_645delAGT	In_Frame_Del	1	0.11	MHHES1	Y	4	10	0	Y
TP53	DGLALIRVE	LIVER	186	p.PPQH190del	c.569_580delCTCCTCAGCATC	In_Frame_Del	4	0.11	JHH5	N	0	0	0	N
TP53	DRNTFRHVV	BONE	208	p.S215del	c.643_645delAGT	In_Frame_Del	1	0.11	MHHES1	Y	4	9	0	N
TP53	DRRENLRKK	LUNG	281	p.TEE284del	c.850_858delACAGAGGAA	In_Frame_Del	3	0.11	HCC1833	Y	1	9	0	N
TP53	DRRTENLRK	BONE	281	p.EE286del	c.856_861delGAAGAG	In_Frame_Del	4	0.11	CAL78	N	2	0	0	N
TP53	DSDGLALIR	LIVER	184	p.PPQH190del	c.569_580delCTCCTCAGCATC	In_Frame_Del	3	0.11	JHH5	N	4	0	0	N
TP53	EVGRCPHHE	UPPER_AERODIGESTIVE_TRACT	171	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	2	0.11	BICR31	N	0	0	0	N
TP53	FRHVVVPYE	BONE	212	p.S215del	c.643_645delAGT	In_Frame_Del	3	0.11	MHHES1	N	3	0	14	N
TP53	GLALIRVEG	LIVER	187	p.PPQH190del	c.569_580delCTCCTCAGCATC	In_Frame_Del	3	0.11	JHH5	N	0	0	0	N
TP53	GRCPHHERC	UPPER_AERODIGESTIVE_TRACT	173	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	1	0.11	BICR31	N	2	0	0	N
TP53	GRDRRENLR	LUNG	279	p.TEE284del	c.850_858delACAGAGGAA	In_Frame_Del	4	0.11	HCC1833	Y	3	9	0	N
TP53	GRDRRTENL	BONE	279	p.EE286del	c.856_861delGAAGAG	In_Frame_Del	2	0.11	CAL78	Y	6	10	0	N
TP53	GSDCTTIYN	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	226	p.H233del	c.697_699delCAC	In_Frame_Del	2	0.11	MEG01	N	1	0	0	Y
TP53	HMTEVGRCP	UPPER_AERODIGESTIVE_TRACT	168	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	3	0.11	BICR31	N	0	0	0	N
TP53	HVVVPYEPP	BONE	214	p.S215del	c.643_645delAGT	In_Frame_Del	1	0.11	MHHES1	N	1	0	0	N
TP53	IYNYMCNSS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	232	p.H233del	c.697_699delCAC	In_Frame_Del	1	0.11	MEG01	N	2	0	21	N
TP53	KTCPVQLCT	CENTRAL_NERVOUS_SYSTEM	139	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	2	0.11	YKG1	N	2	0	0	N
TP53	LALIRVEGN	LIVER	188	p.PPQH190del	c.569_580delCTCCTCAGCATC	In_Frame_Del	2	0.11	JHH5	N	2	0	1	N
TP53	LCTPPPGTR	CENTRAL_NERVOUS_SYSTEM	145	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	2	0.11	YKG1	N	3	0	0	N
TP53	MTEVGRCPH	UPPER_AERODIGESTIVE_TRACT	169	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	4	0.11	BICR31	N	1	0	0	N
TP53	NTFRHVVVP	BONE	210	p.S215del	c.643_645delAGT	In_Frame_Del	2	0.11	MHHES1	N	0	0	0	N
TP53	PGRDRRENL	LUNG	278	p.TEE284del	c.850_858delACAGAGGAA	In_Frame_Del	3	0.11	HCC1833	N	4	0	0	N
TP53	PGRDRRTEN	BONE	278	p.EE286del	c.856_861delGAAGAG	In_Frame_Del	1	0.11	CAL78	N	0	0	0	N
TP53	PVQLCTPPP	CENTRAL_NERVOUS_SYSTEM	142	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	5	0.11	YKG1	N	0	0	0	N
TP53	QHMTEVGRC	UPPER_AERODIGESTIVE_TRACT	167	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	2	0.11	BICR31	N	2	0	0	N
TP53	QLCTPPPGT	CENTRAL_NERVOUS_SYSTEM	144	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	3	0.11	YKG1	N	3	0	0	Y
TP53	QSQHMTEVG	UPPER_AERODIGESTIVE_TRACT	165	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	1	0.11	BICR31	N	0	0	0	N
TP53	RDRRENLRK	LUNG	280	p.TEE284del	c.850_858delACAGAGGAA	In_Frame_Del	3	0.11	HCC1833	N	0	0	0	N
TP53	RDRRTENLR	BONE	280	p.EE286del	c.856_861delGAAGAG	In_Frame_Del	3	0.11	CAL78	N	1	0	0	N
TP53	RENLRKKGE	LUNG	283	p.TEE284del	c.850_858delACAGAGGAA	In_Frame_Del	1	0.11	HCC1833	N	0	0	0	N
TP53	RHVVVPYEP	BONE	213	p.S215del	c.643_645delAGT	In_Frame_Del	2	0.11	MHHES1	N	0	0	0	N
TP53	RNTFRHVVV	BONE	209	p.S215del	c.643_645delAGT	In_Frame_Del	1	0.11	MHHES1	N	3	0	0	N
TP53	RRENLRKKG	LUNG	282	p.TEE284del	c.850_858delACAGAGGAA	In_Frame_Del	2	0.11	HCC1833	N	1	0	0	Y
TP53	RRTENLRKK	BONE	282	p.EE286del	c.856_861delGAAGAG	In_Frame_Del	3	0.11	CAL78	N	2	0	0	N
TP53	RTENLRKKG	BONE	283	p.EE286del	c.856_861delGAAGAG	In_Frame_Del	2	0.11	CAL78	N	2	0	0	N
TP53	SDCTTIYNY	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	227	p.H233del	c.697_699delCAC	In_Frame_Del	3	0.11	MEG01	N	3	0	0	N
TP53	SDGLALIRV	LIVER	185	p.PPQH190del	c.569_580delCTCCTCAGCATC	In_Frame_Del	4	0.11	JHH5	Y	4	9	0	N
TP53	SDSDGLALI	LIVER	183	p.PPQH190del	c.569_580delCTCCTCAGCATC	In_Frame_Del	2	0.11	JHH5	Y	3	9	0	N
TP53	SQHMTEVGR	UPPER_AERODIGESTIVE_TRACT	166	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	1	0.11	BICR31	N	5	0	0	N
TP53	TCPVQLCTP	CENTRAL_NERVOUS_SYSTEM	140	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	3	0.11	YKG1	N	0	0	0	N
TP53	TENLRKKGE	BONE	284	p.EE286del	c.856_861delGAAGAG	In_Frame_Del	1	0.11	CAL78	N	0	0	0	N
TP53	TEVGRCPHH	UPPER_AERODIGESTIVE_TRACT	170	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	3	0.11	BICR31	N	1	0	0	N
TP53	TFRHVVVPY	BONE	211	p.S215del	c.643_645delAGT	In_Frame_Del	3	0.11	MHHES1	Y	3	11	0	N
TP53	TIYNYMCNS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	231	p.H233del	c.697_699delCAC	In_Frame_Del	2	0.11	MEG01	N	0	0	0	N
TP53	TTIYNYMCN	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	230	p.H233del	c.697_699delCAC	In_Frame_Del	2	0.11	MEG01	N	2	0	0	N
TP53	VGRCPHHER	UPPER_AERODIGESTIVE_TRACT	172	p.173_174VR>G	c.518_520delTGA	In_Frame_Del	1	0.11	BICR31	N	1	0	2	N
TP53	VGSDCTTIY	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	225	p.H233del	c.697_699delCAC	In_Frame_Del	1	0.11	MEG01	N	7	0	11	Y
TP53	VQLCTPPPG	CENTRAL_NERVOUS_SYSTEM	143	p.146_149WVDS>C	c.438_446delGGTTGATTC	In_Frame_Del	4	0.11	YKG1	N	0	0	8	Y
TP53	CSDSDGLAL	LIVER	182	p.PPQH190del	c.569_580delCTCCTCAGCATC	In_Frame_Del	1	0.22	JHH5	N	8	0	0	N
TP53	FRHSVVPYE	LUNG	212	p.V218del	c.652_654delGTG	In_Frame_Del	3	0.22	HCC827	N	3	0	17	N
TP53	FRHSVVPYE	ENDOMETRIUM	212	p.V218del	c.652_654delGTG	In_Frame_Del	3	0.22	RL952	N	3	0	17	N
TP53	HSVVPYEPP	LUNG	214	p.V218del	c.652_654delGTG	In_Frame_Del	2	0.22	HCC827	N	1	0	0	Y
TP53	HSVVPYEPP	ENDOMETRIUM	214	p.V218del	c.652_654delGTG	In_Frame_Del	2	0.22	RL952	N	1	0	0	Y
TP53	NTFRHSVVP	LUNG	210	p.V218del	c.652_654delGTG	In_Frame_Del	1	0.22	HCC827	N	0	0	0	N
TP53	NTFRHSVVP	ENDOMETRIUM	210	p.V218del	c.652_654delGTG	In_Frame_Del	1	0.22	RL952	N	0	0	0	N
TP53	RHSVVPYEP	LUNG	213	p.V218del	c.652_654delGTG	In_Frame_Del	3	0.22	HCC827	N	0	0	0	N
TP53	RHSVVPYEP	ENDOMETRIUM	213	p.V218del	c.652_654delGTG	In_Frame_Del	3	0.22	RL952	N	0	0	0	N
TP53	SVVPYEPPE	LUNG	215	p.V218del	c.652_654delGTG	In_Frame_Del	1	0.22	HCC827	N	0	0	0	Y
TP53	SVVPYEPPE	ENDOMETRIUM	215	p.V218del	c.652_654delGTG	In_Frame_Del	1	0.22	RL952	N	0	0	0	Y
TP53	TFRHSVVPY	LUNG	211	p.V218del	c.652_654delGTG	In_Frame_Del	2	0.22	HCC827	N	3	0	0	N
TP53	TFRHSVVPY	ENDOMETRIUM	211	p.V218del	c.652_654delGTG	In_Frame_Del	2	0.22	RL952	N	3	0	0	N