Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE


Result Reset Search:
ProteinNeoepitopesTissuePositionProt MutationcDNA MutationMutation TypeNum MismatchPromiscuity (%)Cell LineCTLMHC INHLApredMHC IIBcell
SMAD4ESLVKKLKDBREAST41p.EKK49delc.145_153delGAGAAAAAAIn_Frame_Del10.11HCC1428N000N
SMAD4KKLKDELDSBREAST45p.EKK49delc.145_153delGAGAAAAAAIn_Frame_Del20.11HCC1428N100N
SMAD4KLKDELDSLBREAST46p.EKK49delc.145_153delGAGAAAAAAIn_Frame_Del20.11HCC1428Y13160N
SMAD4LKDELDSLIBREAST47p.EKK49delc.145_153delGAGAAAAAAIn_Frame_Del10.11HCC1428N300N
SMAD4LVKKLKDELBREAST43p.EKK49delc.145_153delGAGAAAAAAIn_Frame_Del30.11HCC1428N709N
SMAD4SLVKKLKDEBREAST42p.EKK49delc.145_153delGAGAAAAAAIn_Frame_Del20.11HCC1428N000N
SMAD4VKKLKDELDBREAST44p.EKK49delc.145_153delGAGAAAAAAIn_Frame_Del30.11HCC1428N000N