Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PTEN | AAIHCKAGT | OVARY | 120 | p.KGR128del | c.380_388delGAAAGGGAC | In_Frame_Del | 1 | 0.11 | A2780 | N | 3 | 0 | 0 | N | ||||||||||||
| PTEN | AGTGVMICA | OVARY | 126 | p.KGR128del | c.380_388delGAAAGGGAC | In_Frame_Del | 2 | 0.11 | A2780 | N | 0 | 0 | 0 | N | ||||||||||||
| PTEN | AIHCKAGTG | OVARY | 121 | p.KGR128del | c.380_388delGAAAGGGAC | In_Frame_Del | 1 | 0.11 | A2780 | N | 0 | 0 | 0 | N | ||||||||||||
| PTEN | CKAGTGVMI | OVARY | 124 | p.KGR128del | c.380_388delGAAAGGGAC | In_Frame_Del | 3 | 0.11 | A2780 | N | 2 | 0 | 0 | N | ||||||||||||
| PTEN | EGVYRNIDD | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 43 | p.N49del | c.142_144delAAC | In_Frame_Del | 2 | 0.11 | PCM6 | N | 0 | 0 | 0 | N | ||||||||||||
| PTEN | GVYRNIDDV | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 44 | p.N49del | c.142_144delAAC | In_Frame_Del | 3 | 0.11 | PCM6 | Y | 8 | 11 | 0 | N | ||||||||||||
| PTEN | HCKAGTGVM | OVARY | 123 | p.KGR128del | c.380_388delGAAAGGGAC | In_Frame_Del | 3 | 0.11 | A2780 | N | 3 | 0 | 0 | N | ||||||||||||
| PTEN | IHCKAGTGV | OVARY | 122 | p.KGR128del | c.380_388delGAAAGGGAC | In_Frame_Del | 2 | 0.11 | A2780 | N | 3 | 0 | 0 | N | ||||||||||||
| PTEN | IYPNIAMGF | ENDOMETRIUM | 28 | p.I33del | c.94_96delATT | In_Frame_Del | 4 | 0.11 | HEC151 | N | 9 | 0 | 6 | N | ||||||||||||
| PTEN | KAGTGVMIC | OVARY | 125 | p.KGR128del | c.380_388delGAAAGGGAC | In_Frame_Del | 2 | 0.11 | A2780 | N | 2 | 0 | 0 | N | ||||||||||||
| PTEN | LEGVYRNID | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42 | p.N49del | c.142_144delAAC | In_Frame_Del | 2 | 0.11 | PCM6 | N | 0 | 0 | 0 | N | ||||||||||||
| PTEN | LTYIYPNIA | ENDOMETRIUM | 25 | p.I33del | c.94_96delATT | In_Frame_Del | 1 | 0.11 | HEC151 | N | 5 | 0 | 10 | N | ||||||||||||
| PTEN | NIAMGFPAE | ENDOMETRIUM | 31 | p.I33del | c.94_96delATT | In_Frame_Del | 1 | 0.11 | HEC151 | N | 0 | 0 | 0 | N | ||||||||||||
| PTEN | PNIAMGFPA | ENDOMETRIUM | 30 | p.I33del | c.94_96delATT | In_Frame_Del | 2 | 0.11 | HEC151 | N | 0 | 0 | 0 | N | ||||||||||||
| PTEN | RLEGVYRNI | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 41 | p.N49del | c.142_144delAAC | In_Frame_Del | 1 | 0.11 | PCM6 | Y | 6 | 16 | 0 | N | ||||||||||||
| PTEN | RNIDDVVRF | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47 | p.N49del | c.142_144delAAC | In_Frame_Del | 1 | 0.11 | PCM6 | Y | 9 | 12 | 0 | N | ||||||||||||
| PTEN | TYIYPNIAM | ENDOMETRIUM | 26 | p.I33del | c.94_96delATT | In_Frame_Del | 2 | 0.11 | HEC151 | Y | 4 | 10 | 0 | N | ||||||||||||
| PTEN | VYRNIDDVV | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 45 | p.N49del | c.142_144delAAC | In_Frame_Del | 3 | 0.11 | PCM6 | N | 6 | 0 | 0 | N | ||||||||||||
| PTEN | YIYPNIAMG | ENDOMETRIUM | 27 | p.I33del | c.94_96delATT | In_Frame_Del | 3 | 0.11 | HEC151 | Y | 2 | 9 | 1 | N | ||||||||||||
| PTEN | YPNIAMGFP | ENDOMETRIUM | 29 | p.I33del | c.94_96delATT | In_Frame_Del | 3 | 0.11 | HEC151 | N | 3 | 0 | 0 | N | ||||||||||||
| PTEN | YRNIDDVVR | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 46 | p.N49del | c.142_144delAAC | In_Frame_Del | 2 | 0.11 | PCM6 | N | 5 | 0 | 6 | N | ||||||||||||
| PTEN | GTGVMICAY | OVARY | 127 | p.KGR128del | c.380_388delGAAAGGGAC | In_Frame_Del | 1 | 0.33 | A2780 | N | 8 | 0 | 0 | N | ||||||||||||
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