Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FBXW7 | DEEEEEEEM | KIDNEY | 112 | p.117_118insEE | c.351_352insGAGGAG | In_Frame_Ins | 2 | 0.11 | OSRC2 | N | 6 | 0 | 0 | N | ||||||||||||
| FBXW7 | EEEEEEEMD | KIDNEY | 113 | p.117_118insEE | c.351_352insGAGGAG | In_Frame_Ins | 1 | 0.11 | OSRC2 | N | 0 | 0 | 0 | N | ||||||||||||
| FBXW7 | EEEEEEMDQ | KIDNEY | 114 | p.117_118insEE | c.351_352insGAGGAG | In_Frame_Ins | 1 | 0.11 | OSRC2 | N | 0 | 0 | 0 | N | ||||||||||||
| FBXW7 | GSKRRRTPG | CENTRAL_NERVOUS_SYSTEM | 9 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 1 | 0.11 | GAMG | N | 1 | 0 | 0 | N | ||||||||||||
| FBXW7 | KRRRTPGGS | CENTRAL_NERVOUS_SYSTEM | 11 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 3 | 0.11 | GAMG | N | 2 | 0 | 0 | Y | ||||||||||||
| FBXW7 | PGGSLRGNP | CENTRAL_NERVOUS_SYSTEM | 16 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 1 | 0.11 | GAMG | N | 0 | 0 | 0 | N | ||||||||||||
| FBXW7 | RRRTPGGSL | CENTRAL_NERVOUS_SYSTEM | 12 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 3 | 0.11 | GAMG | N | 5 | 0 | 0 | N | ||||||||||||
| FBXW7 | RRTPGGSLR | CENTRAL_NERVOUS_SYSTEM | 13 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 2 | 0.11 | GAMG | Y | 3 | 9 | 0 | Y | ||||||||||||
| FBXW7 | RTPGGSLRG | CENTRAL_NERVOUS_SYSTEM | 14 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 2 | 0.11 | GAMG | N | 0 | 0 | 0 | N | ||||||||||||
| FBXW7 | SKRRRTPGG | CENTRAL_NERVOUS_SYSTEM | 10 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 2 | 0.11 | GAMG | N | 0 | 0 | 0 | N | ||||||||||||
| FBXW7 | TPGGSLRGN | CENTRAL_NERVOUS_SYSTEM | 15 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 2 | 0.11 | GAMG | N | 3 | 0 | 0 | N | ||||||||||||
| FBXW7 | VGSKRRRTP | CENTRAL_NERVOUS_SYSTEM | 8 | p.15_16insP | c.45_46insCCT | In_Frame_Ins | 1 | 0.11 | GAMG | N | 0 | 0 | 14 | N | ||||||||||||
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