Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
EGFR	AIKEATSPK	LUNG	743	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	3	0.11	HCC4006	N	2	0	0	N
EGFR	IKEATSPKA	LUNG	744	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	2	0.11	HCC4006	N	2	0	0	N
EGFR	IPVAIKEAT	LUNG	740	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	2	0.11	HCC4006	N	6	0	0	N
EGFR	KEATSPKAN	LUNG	745	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	1	0.11	HCC4006	N	4	0	0	N
EGFR	KIPVAIKEA	LUNG	739	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	1	0.11	HCC4006	N	4	0	0	N
EGFR	PVAIKEATS	LUNG	741	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	3	0.11	HCC4006	N	0	0	0	N
EGFR	VAIKEATSP	LUNG	742	p.ELR746del	c.2236_2244delGAATTAAGA	In_Frame_Del	4	0.11	HCC4006	N	0	0	1	N
EGFR	AIKTSPKAN	LUNG	743	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	3	0.44	HCC2279	N	0	0	0	N
EGFR	AIKTSPKAN	LUNG	743	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	3	0.44	HCC827	N	0	0	0	N
EGFR	AIKTSPKAN	LUNG	743	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	3	0.44	NCIH1650	N	0	0	0	N
EGFR	AIKTSPKAN	LUNG	743	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	3	0.44	PC14	N	0	0	0	N
EGFR	IKTSPKANK	LUNG	744	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	2	0.44	HCC2279	N	1	0	6	N
EGFR	IKTSPKANK	LUNG	744	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	2	0.44	HCC827	N	1	0	6	N
EGFR	IKTSPKANK	LUNG	744	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	2	0.44	NCIH1650	N	1	0	6	N
EGFR	IKTSPKANK	LUNG	744	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	2	0.44	PC14	N	1	0	6	N
EGFR	IPVAIKTSP	LUNG	740	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	3	0.44	HCC2279	N	2	0	0	N
EGFR	IPVAIKTSP	LUNG	740	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	3	0.44	HCC827	N	2	0	0	N
EGFR	IPVAIKTSP	LUNG	740	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	3	0.44	NCIH1650	N	2	0	0	N
EGFR	IPVAIKTSP	LUNG	740	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	3	0.44	PC14	N	2	0	0	N
EGFR	KIPVAIKTS	LUNG	739	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	2	0.44	HCC2279	N	1	0	0	N
EGFR	KIPVAIKTS	LUNG	739	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	2	0.44	HCC827	N	1	0	0	N
EGFR	KIPVAIKTS	LUNG	739	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	2	0.44	NCIH1650	N	1	0	0	N
EGFR	KIPVAIKTS	LUNG	739	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	2	0.44	PC14	N	1	0	0	N
EGFR	KTSPKANKE	LUNG	745	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	1	0.44	HCC2279	N	1	0	0	N
EGFR	KTSPKANKE	LUNG	745	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	1	0.44	HCC827	N	1	0	0	N
EGFR	KTSPKANKE	LUNG	745	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	1	0.44	NCIH1650	N	1	0	0	N
EGFR	KTSPKANKE	LUNG	745	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	1	0.44	PC14	N	1	0	0	N
EGFR	PVAIKTSPK	LUNG	741	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	4	0.44	HCC2279	N	2	0	0	N
EGFR	PVAIKTSPK	LUNG	741	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	4	0.44	HCC827	N	2	0	0	N
EGFR	PVAIKTSPK	LUNG	741	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	4	0.44	NCIH1650	N	2	0	0	N
EGFR	PVAIKTSPK	LUNG	741	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	4	0.44	PC14	N	2	0	0	N
EGFR	VAIKTSPKA	LUNG	742	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	4	0.44	HCC2279	N	6	0	3	N
EGFR	VAIKTSPKA	LUNG	742	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	4	0.44	HCC827	N	6	0	3	N
EGFR	VAIKTSPKA	LUNG	742	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	4	0.44	NCIH1650	N	6	0	3	N
EGFR	VAIKTSPKA	LUNG	742	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	4	0.44	PC14	N	6	0	3	N
EGFR	VKIPVAIKT	LUNG	738	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	1	0.44	HCC2279	N	1	0	3	N
EGFR	VKIPVAIKT	LUNG	738	p.ELREA746del	c.2236_2250delGAATTAAGAGAAGCA	In_Frame_Del	1	0.44	HCC827	N	1	0	3	N
EGFR	VKIPVAIKT	LUNG	738	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	1	0.44	NCIH1650	N	1	0	3	N
EGFR	VKIPVAIKT	LUNG	738	p.ELREA746del	c.2235_2249delGGAATTAAGAGAAGC	In_Frame_Del	1	0.44	PC14	N	1	0	3	N