Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
VHL	DSLFLPISH	KIDNEY	143	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	6	0.11	A498	N	1	0	0	N
VHL	EIWKTTQMC	KIDNEY	186	p.E186fs	c.557_557delA	Frame_Shift_Del	7	0.11	TUHR10TKB	N	1	0	0	N
VHL	FLPISHCQC	KIDNEY	146	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	7	0.11	A498	N	5	0	4	N
VHL	IWKTTQMCR	KIDNEY	187	p.E186fs	c.557_557delA	Frame_Shift_Del	7	0.11	TUHR10TKB	N	2	0	0	N
VHL	KEMPPGCPE	KIDNEY	159	p.E160fs	c.480_481delGC	Frame_Shift_Del	5	0.11	VMRCRCW	N	2	0	0	N
VHL	KTTQMCRKT	KIDNEY	189	p.E186fs	c.557_557delA	Frame_Shift_Del	7	0.11	TUHR10TKB	N	1	0	0	N
VHL	LFLPISHCQ	KIDNEY	145	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	6	0.11	A498	N	0	0	1	N
VHL	LKEMPPGCP	KIDNEY	158	p.E160fs	c.480_481delGC	Frame_Shift_Del	5	0.11	VMRCRCW	N	0	0	0	N
VHL	LNVDSLFLP	KIDNEY	140	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	5	0.11	A498	N	0	0	4	N
VHL	LPISHCQCI	KIDNEY	147	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	6	0.11	A498	N	14	0	4	N
VHL	LYEIWKTTQ	KIDNEY	184	p.E186fs	c.557_557delA	Frame_Shift_Del	6	0.11	TUHR10TKB	N	0	0	0	N
VHL	MPPGCPEPS	KIDNEY	161	p.E160fs	c.480_481delGC	Frame_Shift_Del	5	0.11	VMRCRCW	N	5	0	0	N
VHL	NVDSLFLPI	KIDNEY	141	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	5	0.11	A498	N	2	0	0	N
VHL	PGCPEPSQA	KIDNEY	163	p.E160fs	c.480_481delGC	Frame_Shift_Del	5	0.11	VMRCRCW	N	0	0	0	N
VHL	PISHCQCIL	KIDNEY	148	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	7	0.11	A498	N	0	0	0	N
VHL	PPGCPEPSQ	KIDNEY	162	p.E160fs	c.480_481delGC	Frame_Shift_Del	5	0.11	VMRCRCW	N	0	0	0	N
VHL	QMCRKTWSG	KIDNEY	192	p.E186fs	c.557_557delA	Frame_Shift_Del	7	0.11	TUHR10TKB	N	0	0	0	N
VHL	SLFLPISHC	KIDNEY	144	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	6	0.11	A498	N	5	0	0	N
VHL	SLYEIWKTT	KIDNEY	183	p.E186fs	c.557_557delA	Frame_Shift_Del	5	0.11	TUHR10TKB	N	4	0	0	N
VHL	TLKEMPPGC	KIDNEY	157	p.E160fs	c.480_481delGC	Frame_Shift_Del	5	0.11	VMRCRCW	N	2	0	0	N
VHL	TQMCRKTWS	KIDNEY	191	p.E186fs	c.557_557delA	Frame_Shift_Del	7	0.11	TUHR10TKB	N	0	0	0	N
VHL	TTQMCRKTW	KIDNEY	190	p.E186fs	c.557_557delA	Frame_Shift_Del	7	0.11	TUHR10TKB	N	1	0	0	N
VHL	VDSLFLPIS	KIDNEY	142	p.V142fs	c.426_429delTGAC	Frame_Shift_Del	5	0.11	A498	N	1	0	0	N
VHL	WKTTQMCRK	KIDNEY	188	p.E186fs	c.557_557delA	Frame_Shift_Del	7	0.11	TUHR10TKB	N	3	0	2	N
VHL	YEIWKTTQM	KIDNEY	185	p.E186fs	c.557_557delA	Frame_Shift_Del	7	0.11	TUHR10TKB	N	10	0	15	N