Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE


Result Reset Search:
ProteinNeoepitopesTissuePositionProt MutationcDNA MutationMutation TypeNum MismatchPromiscuity (%)Cell LineCTLMHC INHLApredMHC IIBcell
TP53HHHHTGRLQLARGE_INTESTINE248p.C238fsc.712_725delTGTAACAGTTCCTGFrame_Shift_Del70.22SW1417N000N
TP53HHHTGRLQWLARGE_INTESTINE249p.C238fsc.712_725delTGTAACAGTTCCTGFrame_Shift_Del70.22SW1417N300N
TP53SEWKEICVWSALIVARY_GLAND195p.E180fsc.539_539delAFrame_Shift_Del70.22A253N600N
TP53SEWKEICVWLUNG195p.P191fsc.572_572delCFrame_Shift_Del70.22NCIH522N600N
TP53HHHHTGRLQOESOPHAGUS253p.I251fsc.751_752insAFrame_Shift_Ins70.22KYSE70N000N
TP53HHHTGRLQWOESOPHAGUS254p.I251fsc.751_752insAFrame_Shift_Ins70.22KYSE70N300N
TP53RHPRPRHGHSTOMACH154p.P152fsc.455_456insCFrame_Shift_Ins70.22HGC27N000N
TP53RHPRPRHGHPANCREAS154p.P152fsc.455_456insCFrame_Shift_Ins70.22KP3N000N
TP53TTGWRIFHPHAEMATOPOIETIC_AND_LYMPHOID_TISSUE322p.Q317fsc.949_950insCFrame_Shift_Ins70.22MEC1N000N
TP53TTGWRIFHPOESOPHAGUS322p.N310fsc.929_930insAFrame_Shift_Ins70.22OE19N000N