Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
TNFAIP3	AAPLEAPCL	LARGE_INTESTINE	662	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	11	0	0	N
TNFAIP3	AHCVSSSTE	LARGE_INTESTINE	624	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	ALFCSVRPL	ENDOMETRIUM	466	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	Y	16	9	0	N
TNFAIP3	APCLKDTAR	LARGE_INTESTINE	667	p.F623fs	c.1867_1867delT	Frame_Shift_Del	4	0.11	LOVO	Y	3	9	0	N
TNFAIP3	APLEAPCLK	LARGE_INTESTINE	663	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	3	0	0	N
TNFAIP3	ARSVSLKLR	LARGE_INTESTINE	674	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	3	0	0	N
TNFAIP3	AWGGNAAPL	LARGE_INTESTINE	657	p.F623fs	c.1867_1867delT	Frame_Shift_Del	4	0.11	LOVO	N	6	0	0	N
TNFAIP3	CLKDTARSV	LARGE_INTESTINE	669	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	Y	4	9	0	N
TNFAIP3	CVSSSTEKT	LARGE_INTESTINE	626	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	DFMRPKGQK	LARGE_INTESTINE	685	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	DTARSVSLK	LARGE_INTESTINE	672	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	Y	3	11	0	N
TNFAIP3	EAPCLKDTA	LARGE_INTESTINE	666	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	2	0	0	N
TNFAIP3	EKTNILLLP	LARGE_INTESTINE	632	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	ENKGFAHCV	LARGE_INTESTINE	619	p.F623fs	c.1867_1867delT	Frame_Shift_Del	4	0.11	LOVO	N	1	0	0	N
TNFAIP3	ESTGGLIRP	ENDOMETRIUM	452	p.G455fs	c.1363_1363delG	Frame_Shift_Del	4	0.11	MFE319	N	0	0	0	N
TNFAIP3	FAHCVSSST	LARGE_INTESTINE	623	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	6	0	0	N
TNFAIP3	FMRPKGQKS	LARGE_INTESTINE	686	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	2	0	0	N
TNFAIP3	FRAWGGNAA	LARGE_INTESTINE	655	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	5	10	9	N
TNFAIP3	GFAHCVSSS	LARGE_INTESTINE	622	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	GGLIRPHRQ	ENDOMETRIUM	455	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	0	0	0	N
TNFAIP3	GGNAAPLEA	LARGE_INTESTINE	659	p.F623fs	c.1867_1867delT	Frame_Shift_Del	4	0.11	LOVO	N	0	0	0	N
TNFAIP3	GKSVPQRPG	LARGE_INTESTINE	642	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	GLIRPHRQH	ENDOMETRIUM	456	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	0	0	0	N
TNFAIP3	GNAAPLEAP	LARGE_INTESTINE	660	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	GSRTPFRAW	LARGE_INTESTINE	650	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	3	9	0	N
TNFAIP3	HCVSSSTEK	LARGE_INTESTINE	625	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	2	0	0	N
TNFAIP3	HPALFCSVR	ENDOMETRIUM	464	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	Y	4	9	0	N
TNFAIP3	HRQHPALFC	ENDOMETRIUM	461	p.G455fs	c.1363_1363delG	Frame_Shift_Del	5	0.11	MFE319	N	2	0	0	N
TNFAIP3	ILLLPQGKS	LARGE_INTESTINE	636	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	11	N
TNFAIP3	IRDFMRPKG	LARGE_INTESTINE	683	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	1	0	5	Y
TNFAIP3	IRPHRQHPA	ENDOMETRIUM	458	p.G455fs	c.1363_1363delG	Frame_Shift_Del	5	0.11	MFE319	N	6	0	18	Y
TNFAIP3	KDTARSVSL	LARGE_INTESTINE	671	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	6	0	0	N
TNFAIP3	KGFAHCVSS	LARGE_INTESTINE	621	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	1	0	0	N
TNFAIP3	KLRIRDFMR	LARGE_INTESTINE	680	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	Y	8	10	0	Y
TNFAIP3	KSVPQRPGS	LARGE_INTESTINE	643	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	1	0	0	N
TNFAIP3	KTNILLLPQ	LARGE_INTESTINE	633	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	2	0	0	N
TNFAIP3	LEAPCLKDT	LARGE_INTESTINE	665	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	5	0	0	N
TNFAIP3	LFCSVRPLP	ENDOMETRIUM	467	p.G455fs	c.1363_1363delG	Frame_Shift_Del	5	0.11	MFE319	N	0	0	0	N
TNFAIP3	LIRPHRQHP	ENDOMETRIUM	457	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	0	0	0	N
TNFAIP3	LKDTARSVS	LARGE_INTESTINE	670	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	1	0	0	N
TNFAIP3	LKLRIRDFM	LARGE_INTESTINE	679	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	7	0	8	Y
TNFAIP3	LLLPQGKSV	LARGE_INTESTINE	637	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	7	0	0	N
TNFAIP3	LLPQGKSVP	LARGE_INTESTINE	638	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	LPQGKSVPQ	LARGE_INTESTINE	639	p.F623fs	c.1867_1867delT	Frame_Shift_Del	4	0.11	LOVO	N	2	0	0	Y
TNFAIP3	LRIRDFMRP	LARGE_INTESTINE	681	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	1	0	9	N
TNFAIP3	MRPKGQKSN	LARGE_INTESTINE	687	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	2	0	6	N
TNFAIP3	NAAPLEAPC	LARGE_INTESTINE	661	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	2	0	0	N
TNFAIP3	NILLLPQGK	LARGE_INTESTINE	635	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	4	0	0	N
TNFAIP3	NKGFAHCVS	LARGE_INTESTINE	620	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	1	0	0	N
TNFAIP3	PALFCSVRP	ENDOMETRIUM	465	p.G455fs	c.1363_1363delG	Frame_Shift_Del	5	0.11	MFE319	N	0	0	0	N
TNFAIP3	PCLKDTARS	LARGE_INTESTINE	668	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	PFRAWGGNA	LARGE_INTESTINE	654	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	PGSRTPFRA	LARGE_INTESTINE	649	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	PHRQHPALF	ENDOMETRIUM	460	p.G455fs	c.1363_1363delG	Frame_Shift_Del	5	0.11	MFE319	N	0	0	0	N
TNFAIP3	PLEAPCLKD	LARGE_INTESTINE	664	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	PQGKSVPQR	LARGE_INTESTINE	640	p.F623fs	c.1867_1867delT	Frame_Shift_Del	4	0.11	LOVO	N	1	0	0	N
TNFAIP3	PQRPGSRTP	LARGE_INTESTINE	646	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	Y
TNFAIP3	QGKSVPQRP	LARGE_INTESTINE	641	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	QHPALFCSV	ENDOMETRIUM	463	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	4	0	0	N
TNFAIP3	QRPGSRTPF	LARGE_INTESTINE	647	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	5	0	0	N
TNFAIP3	RAWGGNAAP	LARGE_INTESTINE	656	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	RDFMRPKGQ	LARGE_INTESTINE	684	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	Y
TNFAIP3	RIRDFMRPK	LARGE_INTESTINE	682	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	2	10	0	Y
TNFAIP3	RPGSRTPFR	LARGE_INTESTINE	648	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	4	0	0	N
TNFAIP3	RPHRQHPAL	ENDOMETRIUM	459	p.G455fs	c.1363_1363delG	Frame_Shift_Del	5	0.11	MFE319	Y	17	11	0	Y
TNFAIP3	RQHPALFCS	ENDOMETRIUM	462	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	2	0	0	N
TNFAIP3	RSVSLKLRI	LARGE_INTESTINE	675	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	8	0	0	N
TNFAIP3	RTPFRAWGG	LARGE_INTESTINE	652	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	SLKLRIRDF	LARGE_INTESTINE	678	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	Y	4	9	0	N
TNFAIP3	SRTPFRAWG	LARGE_INTESTINE	651	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	Y	1	9	0	N
TNFAIP3	SSSTEKTNI	LARGE_INTESTINE	628	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	4	0	0	N
TNFAIP3	SSTEKTNIL	LARGE_INTESTINE	629	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	10	0	0	N
TNFAIP3	STEKTNILL	LARGE_INTESTINE	630	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	7	11	0	N
TNFAIP3	STGGLIRPH	ENDOMETRIUM	453	p.G455fs	c.1363_1363delG	Frame_Shift_Del	5	0.11	MFE319	N	0	0	0	N
TNFAIP3	SVPQRPGSR	LARGE_INTESTINE	644	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	Y	5	10	0	N
TNFAIP3	SVSLKLRIR	LARGE_INTESTINE	676	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	Y	4	9	0	N
TNFAIP3	TARSVSLKL	LARGE_INTESTINE	673	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	10	0	0	N
TNFAIP3	TEKTNILLL	LARGE_INTESTINE	631	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	Y	9	10	0	N
TNFAIP3	TGGLIRPHR	ENDOMETRIUM	454	p.G455fs	c.1363_1363delG	Frame_Shift_Del	6	0.11	MFE319	N	1	0	0	N
TNFAIP3	TNILLLPQG	LARGE_INTESTINE	634	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	0	N
TNFAIP3	TPFRAWGGN	LARGE_INTESTINE	653	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	5	0	0	N
TNFAIP3	VPQRPGSRT	LARGE_INTESTINE	645	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	5	0	0	N
TNFAIP3	VSLKLRIRD	LARGE_INTESTINE	677	p.F623fs	c.1867_1867delT	Frame_Shift_Del	5	0.11	LOVO	N	0	0	4	N
TNFAIP3	VSSSTEKTN	LARGE_INTESTINE	627	p.F623fs	c.1867_1867delT	Frame_Shift_Del	6	0.11	LOVO	N	0	0	0	N
TNFAIP3	WGGNAAPLE	LARGE_INTESTINE	658	p.F623fs	c.1867_1867delT	Frame_Shift_Del	4	0.11	LOVO	N	2	0	0	N
TNFAIP3	ALCGAENER	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	94	p.L92fs	c.274_275insTTGTGGCGCT	Frame_Shift_Ins	5	0.11	SUPHD1	N	5	0	0	N
TNFAIP3	KLVALCGAE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	91	p.L92fs	c.274_275insTTGTGGCGCT	Frame_Shift_Ins	4	0.11	SUPHD1	N	0	0	0	N
TNFAIP3	LVALCGAEN	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	92	p.L92fs	c.274_275insTTGTGGCGCT	Frame_Shift_Ins	5	0.11	SUPHD1	N	0	0	3	Y
TNFAIP3	VALCGAENE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	93	p.L92fs	c.274_275insTTGTGGCGCT	Frame_Shift_Ins	5	0.11	SUPHD1	N	0	0	0	N